F-box/WD repeat-containing protein 10 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''FBXW10''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by

SKP1 S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the ''SKP1'' gene. This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box ...

(MIM 601434),

cullin Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form ''Cullin-RING ubiquitin ligases'' (CRLs) that are highly div ...

(see

CUL1 Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF ( SKP1-CUL1- F-box protein) E3 ubi ...

; MIM 603034), and F-box proteins, act as protein-ubiquitin

ligases In biochemistry, a ligase is an enzyme that can catalyze the joining ( ligation) of two molecules by forming a new chemical bond. This is typically via hydrolysis of a small pendant chemical group on one of the molecules, typically resulting in ...

. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004). upplied by OMIMref name="entrez" /> Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).

References

Further reading