Clofedanol (
INN) or chlophedianol (
BAN
Ban, or BAN, may refer to:
Law
* Ban (law), a decree that prohibits something, sometimes a form of censorship, being denied from entering or using the place/item
** Imperial ban (''Reichsacht''), a form of outlawry in the medieval Holy Roman ...
) is a centrally acting
cough suppressant
Cold medicines are a group of medicinal, medications taken individually or in Combination drug, combination as a Symptomatic treatment, treatment for the symptoms of the common cold and similar conditions of the upper respiratory tract. The t ...
used in the treatment of dry cough. Clofedanol has
local anesthetic,
antispasmodic, and
antihistamine properties, and may have
anticholinergic effects at high doses.
Side effects
Adverse effects may include irritability, drowsiness, nightmares, vertigo, nausea or vomiting, visual disturbances or hallucinations, and
urticaria. There are potential interactions with other anticholinergics, CNS depressants, and alcohol.
Pharmacology
Unlike many other antitussive drugs such as
dextromethorphan, it binds poorly to the
sigma-1 receptor.
Society and culture
Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process and its safety and efficacy data are limited. It was formerly sold over-the-counter in the United States under the trade name Ulo, as a syrup with a dosage of 25 mg/5 mL; however, it has been withdrawn from the market.
It is marketed in
Canada under the trade name Ulone. GM Pharmaceuticals owns the patents to 113 combinations with Chlophedianol and was the first company to launch the cough suppressant in the United States.
It is sold in
Japan
Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...
as an over-the-counter drug under the name Coldrin. It has been marketed in Germany as Pectolitan and in Spain as Gentos.
See also
*
Azacyclonol
Azacyclonol (trade names Ataractan, Calmeran, Frenoton, Frenquel, Psychosan), also known as γ-pipradrol, is a drug which is an ataractive; an agent which diminishes hallucinations in psychotic individuals. It has also been called a tranquili ...
References
Antitussives
H1 receptor antagonists
Chloroarenes
Tertiary alcohols
Dimethylamino compounds
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