The second season of ''

House A house is a single-unit residential building. It may range in complexity from a rudimentary hut to a complex structure of wood, masonry, concrete or other material, outfitted with plumbing, electrical, and heating, ventilation, and air c ...

'' premiered on September 13, 2005 and ended on May 23, 2006. During the season, House tries to cope with his feelings for his ex-girlfriend Stacy Warner, who, after he diagnosed her husband with

acute intermittent porphyria Acute intermittent porphyria (AIP) is a rare Metabolism, metabolic disorder affecting the production of heme resulting from a deficiency of the enzyme porphobilinogen deaminase. It is the most common of the acute porphyrias. Signs and symptoms Th ...

, has taken a job in the legal department of Princeton-Plainsboro Teaching Hospital.

Sela Ward Sela Ann Ward (born July 11, 1956) is an American actress. Her breakthrough TV role was as Teddy Reed in the NBC drama series ''Sisters'' (1991–96), for which she received her first Primetime Emmy Award for Outstanding Lead Actress in a Drama ...

's chemistry with

Hugh Laurie James Hugh Calum Laurie (; born 11 June 1959) is an English actor, comedian, singer, musician and writer. He first gained professional recognition as a member of the English comedy double act Fry and Laurie with Stephen Fry. Fry and Laurie act ...

in the final two episodes of the first season was strong enough to have her character return in seven episodes of the second season.

Cast and characters

Main cast

as Dr. Gregory House *

Lisa Edelstein Lisa Edelstein ( ; born May 21, 1966) is an American actress and artist. She is known for playing Dr. Lisa Cuddy on the Fox medical drama series ''House'' (2004–2011). Between 2014 and 2018, Edelstein starred as Abby McCarthy in the Bravo s ...

as Dr. Lisa Cuddy *

Omar Epps Omar Hashim Epps (born July 20, 1973) is an American actor, rapper, and producer. Epps's film roles include ''Juice (1992 film), Juice'', ''Higher Learning'', ''The Wood'', ''In Too Deep (1999 film), In Too Deep'', and ''Love & Basketball''. His ...

as Dr. Eric Foreman *

Robert Sean Leonard Robert Lawrence Leonard (born February 28, 1969), known professionally as Robert Sean Leonard, is an American actor. He is best known for his portrayal of Neil Perry in the drama film ''Dead Poets Society'' (1989) and Dr. James Wilson in the med ...

as Dr. James Wilson *

Jennifer Morrison Jennifer Marie Morrison (born April 12, 1979) is an American actress and director. She is most known for her roles as Dr. Allison Cameron in the medical-drama series ''House'' (2004–2012) and Emma Swan in the ABC adventure-fantasy series '' ...

as Dr. Allison Cameron *

Jesse Spencer Jesse Gordon Spencer (born 12 February 1979) is an Australian actor. He is known for his roles as Billy Kennedy on the Australian soap opera ''Neighbours'' (1994–2000, 2005, 2022), for which he was nominated for two Logie Awards, Dr. Robert ...

as Dr. Robert Chase

Recurring cast

Stacy Warner Stacy Warner is a fictional recurring character portrayed by Sela Ward on the medical drama ''House''. She was in a relationship with Dr. Gregory House ( Hugh Laurie), when a clotted aneurysm in his right thigh led to an infarction during a g ...

*Stephanie Venditto as Nurse Brenda Previn *

Currie Graham Currie Graham (born February 26, 1967) is a Canadian stage, film and television actor. While primarily recognized as a TV actor, he has numerous film credits, including the action thrillers '' Rancid'' and '' Assault on Precinct 13''. Early li ...

as Mark Warner *

Diane Baker Diane Carol Baker (born February 25, 1938) is an American actress, producer and educator whose career spanned over 50 years. Early life Baker was born February 25, 1938 at Hollywood Presbyterian Hospital in Hollywood, Los Angeles, Californi ...

Blythe House Blythe House is a listed building located at 23 Blythe Road, West Kensington, London Borough of Hammersmith and Fulham, UK. Originally built as the headquarters of the Post Office Savings Bank, it is next used as a store and archive by the V ...

R. Lee Ermey Ronald Lee Ermey (March 24, 1944 – April 15, 2018) was an American actor and United States Marine Corps, U.S. Marine drill instructor. He achieved fame for his role as Gunnery sergeant, Gunnery Sergeant Hartman in the 1987 film ''Full Met ...

John House John William House (15 September 1919 – 31 January 1984) was a British geographer, who was Halford Mackinder Professor of Geography at the University of Oxford from 1974 to 1983. Life House was born in 1919 and educated at Bradford Gramma ...

* Charles S. Dutton as Rodney Foreman *

Ron Perkins Ron Perkins (born March 29, 1961) is an American actor. He is known for his role as Mendel Stromm in ''Spider-Man'' (2002). He also appeared in ''The Prestige'' (2006) as the manager of a hotel visited by Hugh Jackman's character in Colorado Spr ...

as Dr. Ron Simpson

Guest cast

Laura Allen Laura Allen (born March 21, 1974) is an American actress. She is known for her roles on the ABC Daytime soap opera ''All My Children'' (2000–2002) and the USA Network television series ''The 4400'' (2004–2005, 2007). She has also been a reg ...

Yareli Arizmendi Yareli Arizmendi (born 1964) is a Mexican actress, writer, and director. Born in Mexico City, Arizmendi went to high school in Kansas (Academy of Mt. St. Scholastica), then received a BA in Political Science and her MFA in Theatre from the graduat ...

Matthew John Armstrong Matthew John Armstrong (born August 28, 1973) is an American actor. He is known for roles in ''Turks'' (1999), ''The Profile'' (2010) and ''Heroes'' (2006). Early life Armstrong attended Naperville Central High School in Naperville, Illinois, ...

Mackenzie Astin Mackenzie Alexander Astin (born May 12, 1973) is an American actor. Early and personal life Astin was born on May 12, 1973, in Los Angeles, California, the son of actress Patty Duke and actor John Astin. His half brother is actor Sean Astin. H ...

, Christine Avila,

Marshall Bell Archibald Marshall Bell (born September 28, 1942) is an American character actor. He has appeared in many character roles in movies and television. He is known for roles in '' A Nightmare on Elm Street 2: Freddy's Revenge'' (1985), '' Stand b ...

, Peter Birkenhead,

Tamara Braun Tamara Braun (born April 18, 1971) is an American actress known for her work on daytime television. She portrayed the role of Carly Corinthos on ''General Hospital'' from 2001–2005 and Reese Williams on ''All My Children'' from 2008 to 200 ...

Yvette Nicole Brown Yvette Nicole Brown (born August 12, 1971) is an American actress. She starred as Shirley Bennett on the NBC sitcom ''Community'', as Dani in the 2015 reboot of '' The Odd Couple'' on CBS, and as Dina Rose on the ABC sitcom '' The Mayor''. Br ...

Dan Butler Daniel Eugene Butler (born December 2, 1954) is an American actor known for his role as Bob "Bulldog" Briscoe on the TV series ''Frasier'' (1993–2004), later reprising the role in 2024; Art in ''Roseanne'' (1991–1992); for the voice of Mr ...

Scott Michael Campbell Scott Michael Campbell (born August 14, 1971) is an American actor, writer, producer and director. Campbell is best known from his roles in ''Brokeback Mountain'', ''Push'' and '' Flight of the Phoenix''. Among the roles he has played (many of t ...

Christopher Carley Christopher Murphy Carley (born May 31, 1978) is an American actor who is sometimes credited as Chris Carley. Carley was born in Suffern, New York to Elizabeth and Gerard Carley and grew up in Pearl River. He has two sisters, Cara and Sarah, ...

, Jewel Christian,

Michelle Clunie Michelle Renee Clunie (born November 7, 1969) is an American actress and former ballet dancer. A native of Portland, Oregon, Clunie studied ballet from an early age, earning a scholarship at the Academy of Professional Ballet. In 1992, she starre ...

, Aasha Davis, Thomas Dekker, Stephanie Erb,

Elle Fanning Mary Elle Fanning (born April 9, 1998) is an American actress. Her works include both independent films and blockbusters, and her accolades include a National Board of Review Award, in addition to nominations for a Primetime Emmy Award and ...

, Bruce French,

Erica Gimpel Erica Fawn Gimpel (born June 25, 1964) is an American actress, singer, dancer, and composer. She is best known for her roles on television shows '' Fame'' as Coco Hernandez and on '' Profiler'' as Angel Brown. She is also known for her recurrin ...

Greg Grunberg Gregory Phillip Grunberg (born July 11, 1966) is an American film and television actor known for starring as Eric Weiss in the ABC series '' Alias'', Matt Parkman in the NBC series '' Heroes'', Temmin "Snap" Wexley in '' Star Wars: The Force ...

Wings Hauser Gerald Dwight "Wings" Hauser (December 12, 1947 – March 15, 2025) was an American actor, screenwriter, film director and musician. A prolific character actor, he appeared in over 100 film and television productions since 1967, and was once cal ...

Taraji P. Henson Taraji Penda Henson ( ; born September 11, 1970) is an American actress. Her accolades include a Golden Globe Award, alongside nominations for an Academy Award, six Emmy Awards, and a Tony Award. In 2016 and 2024, ''Time'' named Henson one of ...

Howard Hesseman Howard Hesseman (February 27, 1940 – January 29, 2022) was an American actor known for his television roles as burned-out disc jockey Dr. Johnny Fever on '' WKRP in Cincinnati'' and the lead role of history teacher Charlie Moore on '' Head ...

, Wil Horneff,

Ryan Hurst Ryan Douglas Hurst (born June 19, 1976), also known as Gobind Seva Singh, is an American actor. He is best known for his roles as Gerry Bertier in ''Remember the Titans'' (2000) and Opie Winston in the FX drama series ''Sons of Anarchy'' (2008 ...

, James Immekus,

LL Cool J James Todd Smith (born January 14, 1968), known professionally as LL Cool J (short for Ladies Love Cool James), is an American rapper and actor. He is one of the earliest rappers to achieve commercial success, alongside fellow new school hip ho ...

William Katt William Theodore Katt (born February 16, 1951) is an American actor and musician. He is best known for his starring role as Ralph Hinkley/Hanley on the ABC television series '' The Greatest American Hero'' (1981–1983). Katt first became k ...

Mimi Kennedy Mary Claire "Mimi" Kennedy (born September 25, 1948) is an American actress, author and activist. Best known for her roles in television sitcoms, Kennedy co-starred in numerous short-lived sitcoms before her role as Ruth Sloan on '' Homefront'' ...

, Edward Kerr,

Elias Koteas Elias Koteas (; ; born March 11, 1961) is a Canadian actor who has performed in lead and supporting roles in numerous films and television series. He won the Canadian Screen Award for Best Supporting Actor for his role in the film '' Ararat'' (20 ...

Nathan Kress Nathan Karl Kress (born November 18, 1992) is an American actor. He began his career at the age of three, notably appearing in several television commercials and providing the voices of Easy and Tough Pup in the comedy-drama film ''Babe: Pig in ...

Tom Lenk Thomas Loren Lenk (born June 16, 1976) is an American film and television actor, best known for portraying the character of Andrew Wells in the television series ''Buffy the Vampire Slayer''. Early life Lenk was born in Camarillo, California, th ...

Ron Livingston Ronald Joseph Livingston (born June 5, 1967) is an American actor. He is best known for playing Peter Gibbons in ''Office Space'' (1999) and Captain Lewis Nixon III in the miniseries ''Band of Brothers (miniseries), Band of Brothers'' (2001). Liv ...

Samantha Mathis Samantha Mathis (born May 12, 1970) is an American actress and trade union leader who served as the Vice President, Actors/Performers of SAG-AFTRA from 2015 to 2019. The daughter of actress Bibi Besch, Mathis made her film debut in '' Pump Up ...

Jayma Mays Jamia Suzette "Jayma" Mays (born July 16, 1979) is an American actress. She is known for playing Emma Pillsbury in the Fox musical series '' Glee'' (2009–2015) and for her starring roles in the films ''Red Eye'' (2005), '' Paul Blart: Mall ...

, Eddie Mills,

Cynthia Nixon Cynthia Ellen Nixon (born April 9, 1966) is an American actress, activist, and theater director. For her portrayal of Miranda Hobbes in the HBO series ''Sex and the City'' (1998–2004), she won the Primetime Emmy Award for Outstanding Supportin ...

Michael O'Keefe Michael O'Keefe (born Raymond Peter O'Keefe Jr.; April 24, 1955) is an American actor known for his roles as Danny Noonan in '' Caddyshack''; Ben Meechum in '' The Great Santini,'' for which he received a nomination for the Academy Award for Bes ...

, America Olivo,

Kip Pardue Kevin Ian Pardue (born September 23, 1975) is an American actor and model, who became known for his roles in the films ''But I'm a Cheerleader'' (1999), ''Remember the Titans'' (2000), '' Driven'' (2001), '' The Rules of Attraction'' (2002) and ' ...

Randall Park Randall Park (born March 23, 1974) is an American actor and filmmaker. He is best known for his roles as Agent Jimmy Woo in the Marvel Cinematic Universe, FBI Special Agent Edwin Park in the Netflix series '' The Residence'' (2025), Louis Hu ...

Sasha Pieterse Sasha Pieterse Sheaffer (; born February 17, 1996) is a South African and American actress and singer. She is known for portraying Alison DiLaurentis in the Freeform (TV channel), Freeform series ''Pretty Little Liars'' (2010–2017), and its sp ...

Kristoffer Polaha Kristoffer Polaha is an American actor. He is best known for his starring roles on television as Jason Matthews in ''North Shore (2004 TV series), North Shore'', Nate Bazile, Nathaniel "Baze" Bazile in ''Life Unexpected'', and Henry Butler in '' ...

Clifton Powell Clifton Powell (born March 16, 1956) is an American actor who primarily plays supporting roles in films, such as in '' Ray'' (2004), for which he received an NAACP Image Award for Outstanding Supporting Actor in a Motion Picture nomination. Ca ...

Keri Lynn Pratt Keri Lynn Pratt (born September 23, 1978) is an American retired film and television actress. She is best known for her role as Missy Belknap in '' Jack & Bobby'', and as Dee Vine in her film debut, '' Drive Me Crazy''. Personal life Pratt, who ...

, Cameron Richardson, Charlie Robinson,

Ignacio Serricchio Ignacio Ariel Serricchio (born April 19, 1982) is an Argentine actor. He is known for his role as Diego Alcazar on ''General Hospital'' and as Alejandro "Alex" Chavez on ''The Young and the Restless''. Other roles include Lifetime's '' Witches ...

Vicellous Reon Shannon Vicellous Reon Shannon (born April 11, 1971) is an American actor known for his portrayal of Lesra Martin in the 1999 film '' The Hurricane'', and Keith Palmer, the son of presidential candidate David Palmer in the Fox television series '' 24' ...

, Allison Smith,

Christie Lynn Smith Christie Lynn Smith is an American actress best known for her role as Deardra Farnum in the 2010 film '' The Crazies''. Career Smith grew up mostly in Orange Park, Florida. Since 1991, she has guest starred in numerous television series includ ...

D. B. Sweeney Daniel Bernard Sweeney (born November 14, 1961) is an American actor. He is known for his roles as Jackie Willow in Francis Ford Coppola's '' Gardens of Stone'' (1987), Lt. Phil Lowenthal in '' Memphis Belle'' (1990), and Travis Walton in '' Fire ...

Chris Tallman Christian Tallman (born September 22, 1970) is an American actor and comedian. He is best known for his regular appearances on the Comedy Central programs '' Crossballs'' and ''Reno 911!'' and the Nickelodeon program ''The Thundermans''. Early l ...

Michelle Trachtenberg Michelle Christine Trachtenberg (October 11, 1985 – February 26, 2025) was an American actress. After beginning her career in television commercials at age three, she made her television debut in her first credited role on the Nickelodeon ser ...

Hillary Tuck Hillary Tuck (born July 1, 1978) is an American former actress. She started as a child actress, including roles in the NBC Saturday Morning sitcom '' Hang Time'' (1995–1996) and Disney's '' Honey, I Shrunk the Kids: The TV Show''. She has als ...

Alanna Ubach Alanna Ubach (born October 3, 1975) is an American actress. She is known for her roles as Serena McGuire in ''Legally Blonde'' (2001) and ''Legally Blonde 2'' (2003), Isabel Villalobos in ''Meet the Fockers'' (2004), Maria in '' Sister Act 2: Ba ...

, Stephanie Venditto,

Tom Verica Tom Verica (born May 13, 1964) is an American actor, director, and producer, best known for his role as Sam Keating in the ABC drama ''How to Get Away with Murder'' (2014–2020). He also played Jack Pryor in the NBC critically acclaimed drama ...

, J.R. Villarreal and Julie Warner.

Reception

The season gained high

Nielsen ratings Nielsen Media Research (NMR) is an American firm that measures media audiences, including television, radio, theatre, films (via the AMC Theatres MAP program), and newspapers. Headquartered in New York City, it is best known for the Nielsen rat ...

; "No Reason" was watched by 25.47 million viewers, the show's biggest audience ever at that point. Season two averaged 17.3 million viewers an episode, outperforming season one by 30%. The number of viewers made it the tenth most-watched show of the 2005–2006 television season. Writer

Lawrence Kaplow Lawrence "Larry" Kaplow is an American television writer and producer most notable for his work on the FOX series ''House''. He won the 2005 Writers Guild of America Award for "Outstanding Television Script, Episodic Drama" for the ''House'' episo ...

Cast and characters

Main cast

Recurring cast

Guest cast

Reception

Episodes

DVD releases

References

External links