''Euphorbia helioscopia'', the sun spurge or madwoman's milk, is a species of flowering plant in the spurge family

Euphorbiaceae Euphorbiaceae (), the spurge family, is a large family of flowering plants. In English, they are also commonly called euphorbias, which is also the name of Euphorbia, the type genus of the family. Most spurges, such as ''Euphorbia paralias'', ar ...

. It is a herbaceous

annual plant An annual plant is a plant that completes its life cycle, from germination to the production of seeds, within one growing season, and then dies. Globally, 6% of all plant species and 15% of herbaceous plants (excluding trees and shrubs) are ...

, native to most of

Europe Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east ...

, northern

Africa Africa is the world's second-largest and second-most populous continent after Asia. At about 30.3 million km2 (11.7 million square miles) including adjacent islands, it covers 20% of Earth's land area and 6% of its total surfac ...

, and eastward through most of

Asia Asia ( , ) is the largest continent in the world by both land area and population. It covers an area of more than 44 million square kilometres, about 30% of Earth's total land area and 8% of Earth's total surface area. The continent, which ...

.''Flora Europaea''
''Euphorbia helioscopia''
/ref>Blamey, M. & Grey-Wilson, C. (1989). ''Flora of Britain and Northern Europe''. Additional folk names include wart spurge, summer spurge, umbrella milkweed, and wolf's-milk. Malta Wild Plant

Description

''Euphorbia helioscopia'' is an

growing in

arable land Arable land (from the , "able to be ploughed") is any land capable of being ploughed and used to grow crops.''Oxford English Dictionary'', "arable, ''adj''. and ''n.''" Oxford University Press (Oxford), 2013. Alternatively, for the purposes of a ...

and

disturbed ground In ecology, a disturbance is a change in environmental conditions that causes a pronounced change in an ecosystem. Disturbances often act quickly and with great effect, to alter the physical structure or arrangement of biotic and abiotic element ...

. It grows to 10–50 cm tall, with a single, erect, hairless stem, branching toward the top. The

leaves A leaf (: leaves) is a principal appendage of the stem of a vascular plant, usually borne laterally above ground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", while the leaves, stem, ...

are oval, broadest near the tip, 1.5–3 cm long, with a finely toothed margin. The

flower Flowers, also known as blooms and blossoms, are the reproductive structures of flowering plants ( angiosperms). Typically, they are structured in four circular levels, called whorls, around the end of a stalk. These whorls include: calyx, m ...

s are small, yellow-green, with two to five basal

bract In botany, a bract is a modified or specialized leaf, associated with a reproductive structure such as a flower, inflorescence axis or cone scale. Bracts are usually different from foliage leaves in size, color, shape or texture. They also lo ...

s similar to the leaves but yellower. Flowering lasts from mid-spring to late summer. Similar species include '' Euphorbia rhabdotosperma'', having the appearance of ''E. helioscopia'' with smaller parts and differing seed surface (Iran, North Caucasus, Transcaucasus, Turkey, Turkmenistan).

Uses

Active ingredients extracted from ''Euphorbia helioscopia'' are used in pharmaceutical industry. The plant is used in Chinese traditional medicine. Its extract has been found to inhibit

hepatocellular carcinoma Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. HCC is the third leading cause of cancer-related deaths worldwide. HCC most common ...

''in vivo'' in

mice A mouse (: mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...

Chemistry

''Euphorbia helioscopia'' contains toxic

diterpene Diterpenes are a class of terpenes composed of four isoprene units, often with the molecular formula C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary ...

s and diterpenoids and phorbol esters. These substances are the major skin irritants found in the plant. The plant is considered poisonous when eaten raw.

Nausea Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. It can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the throat. Over 30 d ...

, allergic reactions, skin irritation, vomiting may occur after eating. A number of

tannin Tannins (or tannoids) are a class of astringent, polyphenolic biomolecules that bind to and Precipitation (chemistry), precipitate proteins and various other organic compounds including amino acids and alkaloids. The term ''tannin'' is widel ...

s can be found in ''E. helioscopia''. Helioscopinin-A shows

anti-allergic Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, aller ...

and anti-asthmatic activities in guinea pigs. It is suggested that this compound exerts its activities through antagonism on

leukotriene D4 Leukotriene D4 (LTD4) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. It also increases vascular permeability. LTD4 is released b ...

-induced responses.

References

{{Authority control helioscopia Flora of Africa Flora of Asia Flora of Europe Plants described in 1753 Taxa named by Carl Linnaeus