Etonitazene 5-acetyl analogue (Etoacetazene, 5-acetyldesnitroetonitazene) is a

benzimidazole Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a white solid that appears in form of tabular crystals. Preparation Benzimi ...

derivative with

opioid Opioids are a class of Drug, drugs that derive from, or mimic, natural substances found in the Papaver somniferum, opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, ...

effects, first developed in the 1950s as part of the research that led to better-known compounds such as

etonitazene Etonitazene, also known as EA-4941 or CS-4640, is a List of benzimidazole opioids, benzimidazole opioid, first reported in 1957, that has been shown to have approximately 1,000 to 1,500 times the potency (pharmacology), potency of morphine in anim ...

. It is an analogue of etonitazene where the 5-nitro (NO₂) group has been replaced by an acetyl (COCH₃) group. It is described as having "reduced but still significant" potency compared to etonitazene itself. This compound was also tested as part of a series of

cannabinoid receptor 2 The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the ''CNR2'' gene. It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for ...

agonists, and was found to be active though with fairly low potency of 960 nM at CB₂, and negligible activity at CB₁.

References

Analgesics Designer drugs Benzimidazole opioids Aromatic ethers Diethylamino compounds Ethoxy compounds {{Analgesic-stub

See also

References