Eradication Of Suffering

The eradication of suffering or abolition of suffering is a proposed goal within biotechnology and ethics to eliminate involuntary pain and suffering in all sentient beings. The concept involves using advanced techniques in genetic engineering, neuroscience, and pharmacology to mitigate or prevent negative experiences, with the long-term aim of replacing suffering with states of well-being. It is associated with strands of transhumanism, negative utilitarianism, and animal welfare ethics that advocate for the use of science and technology to reduce or abolish suffering on a global or species-wide scale.

Biology and medicine

The discovery of modern anesthesia in the 19th century was an early breakthrough in the elimination of pain during surgery, but acceptance was not universal. Some medical practitioners at the time believed that anesthesia was an artificial and harmful intervention in the body's natural response to injury. Opposition to anesthesia has since dissipated; however, the prospect of eradicating pain raises similar concerns about interfering with life's natural functions.

People who are naturally incapable of feeling pain or unpleasant sensations due to rare conditions like pain asymbolia or congenital insensitivity to pain have been studied to discover the biological and genetic reasons for their pain-free lives. A Scottish woman with a previously unreported genetic mutation in a FAAH pseudogene (dubbed FAAH-OUT) with resultant elevated anandamide levels was reported in 2019 to be immune to anxiety, unable to experience fear, and insensitive to pain. The frequent burns and cuts she had due to her full hypoalgesia healed quicker than average.

In 1990, '' Medical Hypotheses'' published an article by L. S. Mancini on the "genetic engineering of a world without pain":

The development of gene editing techniques like CRISPR has raised the prospect that "scientists can identify the causes of certain unusual people's physical superpowers and use gene editing to grant them to others." Geneticist George Church has commented on the potential future of replacing pain with a painless sensory system:

Ethics and philosophy

Debate in hedonism and utilitarianism

Ethicists and philosophers in the schools of hedonism and utilitarianism, especially negative utilitarianism, have debated the merits of eradicating suffering. Transhumanist philosopher David Pearce, in ''The Hedonistic Imperative'' (1995), argues that the abolition of suffering is both technically feasible and an issue of moral urgency, stating that: "It is predicted that the world's last unpleasant experience will be a precisely dateable event."

The philosopher Nick Bostrom, director of the Future of Humanity Institute, advises a more cautious approach due to pain's function in protecting individuals from harm. However, Bostrom supports the core idea of using biotechnology to get rid of "a huge amount of unnecessary and undeserved suffering."

Alternative views

It has also been argued that the eradication of suffering through biotechnology may bring about unwanted consequences, and arguments have been made that transhumanism is not the only philosophy worthy of consideration regarding the question of suffering. Many people view suffering as one aspect in a dualist understanding of psychological and physical functioning, without which pleasure could not exist.

Psychological and sociocultural perspectives

Modern psychology recognizes that suffering, while often undesirable, can play a constructive role in human development, resilience, and meaning-making. Existential psychologists such as Viktor Frankl have argued that suffering can be a source of personal growth, purpose, and transcendence, particularly when it is unavoidable. In his work ''Man's Search for Meaning'', Frankl suggests that “suffering ceases to be suffering at the moment it finds a meaning.” This perspective challenges purely hedonistic or utilitarian models that prioritize the elimination of discomfort over its contextual significance.

From a sociocultural standpoint, suffering is also embedded in collective narratives and traditions. Religious and spiritual traditions—including Buddhism, Christianity, and Stoicism—have historically placed suffering at the center of ethical and metaphysical inquiry. For example, the Buddhist concept of ''dukkha'' (suffering) is not something to be eliminated through technology alone but transcended through insight and mental discipline. Critics of technological interventions suggest that an exclusive focus on biological solutions may overlook these cultural and existential dimensions, potentially impoverishing the human experience.

Animal welfare

Reducing animal suffering through biotechnology

In 2009, Adam Shriver suggested replacing animals in factory farming with genetically engineered animals with a reduced or absent capacity to suffer and feel pain. Shriver and McConnachie argued that people who wish to improve animal welfare should support gene editing in addition to plant-based diets and cultured meat.

Katrien Devolder and Matthias Eggel proposed gene editing research animals to remove pain and suffering. This would be an intermediate step towards eventually stopping all experimentation on animals and adopting alternatives.

Wild-animal suffering

Concerning wild-animal suffering, CRISPR-based gene drives have been suggested as a cost-effective way of spreading benign alleles in sexually reproducing species. To limit gene drives spreading indefinitely (for test programmes, for example), the Sculpting Evolution group at the MIT Media Lab developed a self-exhausting form of CRISPR-based gene drive called a "daisy-chain drive." For potential adverse effects of a gene drive, " veral genetic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, including synthetic resistance, reversal drives, and immunizing reversal drives."

Feasibility

According to David Pearce, eradicating suffering is technically feasible by addressing its biological basis, as external changes cannot overcome the genetically constrained hedonic treadmill. Potential solutions include wireheading (direct brain stimulation for uniform bliss), which undermines motivation and evolutionary fitness; designer drugs, offering sustainable well-being without side effects, though impractical for lifelong reliance; and genetic engineering, the most promising approach. Genetic recalibration through hyperthymia-promoting genes could raise hedonic set-points, fostering adaptive well-being, creativity, and productivity while maintaining responsiveness to stimuli. While scientifically achievable, this transformation requires careful ethical and societal considerations to navigate its profound implications.

See also

* Antinaturalism
* Appeal to nature
* Biohappiness
* Effective altruism
* Moral circle expansion
* Pain in animals
* Prioritarianism
* Suffering-focused ethics
* Suffering risks
* Transhumanism
* Wild animal suffering

References

Further reading

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Animal welfare
Axiology
Bioethics
Biotechnology
Concepts in ethics
Genetic engineering
Genome editing
Pain
Suffering
Transhumanism
Utilitarianism