Ephron is a Jewish surname. Notable people with the surname include: * Ephron (biblical figure), Hittite who sold a cave to Abraham according to the Bible *A family of American writers: ** Henry Ephron (1911–1992), father ** Phoebe Ephron (1914–1971), mother ** Amy Ephron (born 1952), daughter ** Delia Ephron (born 1944), daughter ** Hallie Ephron (born 1948), daughter, sometimes writes as G. H. Ephron ** Nora Ephron (1941–2012), daughter * Theron Ephron Catlin (1878–1960), American politician from Missouri

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