Encephalomyocarditis virus is a member of the ''

Picornaviridae Picornaviruses are a group of related nonenveloped RNA viruses which infect vertebrates including fish, mammals, and birds. They are viruses that represent a large family of small, positive-sense, single-stranded RNA viruses with a 30 nm ...

'' family. Infection with the virus causes encephalomyocarditis and reproductive disease in

pig The pig (''Sus domesticus''), also called swine (: swine) or hog, is an omnivorous, domesticated, even-toed, hoofed mammal. It is named the domestic pig when distinguishing it from other members of the genus '' Sus''. Some authorities cons ...

s. Although a variety of

mammals A mammal () is a vertebrate animal of the class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three middle e ...

may host the virus, pigs are classed as the domestic host as they are most easily infected. It is thought to be spread by

rodents Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia ( ), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are n ...

. The disease can be found worldwide but is of greatest economic importance in tropical areas. It is not thought to be

zoonotic A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a virus, bacterium, parasite, fungi, or prion) that can jump from a non-human vertebrate to a human. When h ...

Clinical signs and diagnosis

Piglets that are infected present with

encephalitis Encephalitis is inflammation of the Human brain, brain. The severity can be variable with symptoms including reduction or alteration in consciousness, aphasia, headache, fever, confusion, a stiff neck, and vomiting. Complications may include se ...

myocarditis Myocarditis is inflammation of the cardiac muscle. Myocarditis can progress to inflammatory cardiomyopathy when there is associated ventricular remodeling and cardiac dysfunction due to chronic inflammation. Symptoms can include shortness of bre ...

and sudden death. Mortality rates can be high. If a

sow Sow or SOW may refer to: * Sowing, the process of planting Female animals * Badger * Bear * Guinea pig * Hedgehog * Suidae ** Wild boar ** Pig Arts, entertainment and media * Sow (band), a musical project of Anna Wildsmith * "Sow", a poem by Sy ...

is infected whilst pregnant she may present with a variety of reproductive signs including

infertility In biology, infertility is the inability of a male and female organism to Sexual reproduction, reproduce. It is usually not the natural state of a healthy organism that has reached sexual maturity, so children who have not undergone puberty, whi ...

, mummification,

abortion Abortion is the early termination of a pregnancy by removal or expulsion of an embryo or fetus. Abortions that occur without intervention are known as miscarriages or "spontaneous abortions", and occur in roughly 30–40% of all pregnan ...

still birth Stillbirth is typically defined as fetal death at or after 20 or 28 weeks of pregnancy, depending on the source. It results in a baby born without signs of life. A stillbirth can often result in the feeling of guilt or grief in the mother. T ...

and the birth of weak piglets. A variety of gastrointestinal, respiratory and systemic signs may also be seen as the virus infects multiple body systems. A presumptive diagnosis can be made based on the history and clinical signs. Virus isolation is necessary for definitive diagnosis.

Postmortem examination An autopsy (also referred to as post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death; ...

of piglets may or may not reveal cardiac pathology but

histopathology Histopathology (compound of three Greek words: 'tissue', 'suffering', and '' -logia'' 'study of') is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopatholog ...

should show cardiac and brain abnormalities. Signs in aborted fetuses are highly variable.

References

* Encephalomyocarditis Virus, reviewed and published by Wikivet at http://en.wikivet.net/Encephalomyocarditis_Virus, accessed 06/09/2011 Animal viral diseases Cardioviruses Swine diseases {{Veterinary-med-stub