Pamoic acid, also called embonic acid, is a
2-Naphthoic acid derivative.
Salts and
ester
In chemistry, an ester is a compound derived from an acid (either organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group () of that acid is replaced by an organyl group (R). These compounds contain a distin ...
s of pamoic acid are known as pamoates or embonates. It can be prepared by the reaction of
3-hydroxy-2-naphthoic acid with
formaldehyde.
In pharmacology, the salt form of pamoic acid (pamoate ion) can be used as a
counterion of a drug compound to affect the
dissolution rate of the drug. The presence of multiple oxygen atoms enables significant hydrogen bonding to occur. Hydrogen bonds facilitate the dissolution of compounds in water. Pharmaceutical drugs formulated this way include
cycloguanil pamoate,
hydroxyzine pamoate,
imipramine pamoate,
olanzapine pamoate hydrate,
oxantel pamoate,
pyrantel pamoate, and
pyrvinium pamoate.
Pamoic acid has agonist activity for the
orphan
An orphan is a child whose parents have died, are unknown, or have permanently abandoned them. It can also refer to a child who has lost only one parent, as the Hebrew language, Hebrew translation, for example, is "fatherless". In some languages ...
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related ...
GPR35 by which it activates
ERK and
beta-arrestin2, and causes
antinociceptive activity.
References
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Dicarboxylic acids
2-Naphthols
Naphthoic acids
Alpha hydroxy acids
Diols