Elongin C is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''ELOC''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

Elongin C is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by

RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a Protein complex, multiprotein complex that Transcription (biology), transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNA pol ...

by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The

von Hippel-Lindau tumor suppressor The term () is used in German surnames either as a nobiliary particle indicating a noble patrilineality, or as a simple preposition used by commoners that means or . Nobility directories like the often abbreviate the noble term to ''v.'' I ...

protein binds to elongins B and C, and thereby inhibits transcription elongation.

Interactions

TCEB1 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...

with: *

TCEB2 Elongin B is a protein that in humans is encoded by the ''ELOB'' gene. Function Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymer ...

and *

Von Hippel-Lindau tumor suppressor The term () is used in German surnames either as a nobiliary particle indicating a noble patrilineality, or as a simple preposition used by commoners that means or . Nobility directories like the often abbreviate the noble term to ''v.'' I ...

Function

Interactions

References

Further reading