Elongin B is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ELOB''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by
RNA polymerase II
RNA polymerase II (RNAP II and Pol II) is a Protein complex, multiprotein complex that Transcription (biology), transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNA pol ...
by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The
von Hippel-Lindau tumor suppressor
The term () is used in German surnames either as a nobiliary particle indicating a noble patrilineality, or as a simple preposition used by commoners that means or .
Nobility directories like the often abbreviate the noble term to ''v.'' I ...
protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Interactions
TCEB2 has been shown to
interact
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with:
*
CUL2
Cullin-2 is a protein that in humans is encoded by the ''CUL2'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to p ...
,
TCEB1
Elongin C is a protein that in humans is encoded by the ''ELOC'' gene.
Function
Elongin C is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polyme ...
,Von Hippel-Lindau tumor suppressor
The term () is used in German surnames either as a nobiliary particle indicating a noble patrilineality, or as a simple preposition used by commoners that means or .
Nobility directories like the often abbreviate the noble term to ''v.'' I ...
.
References
Further reading
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External links
PDBe-KB
provides an overview of all the structure information available in the PDB for Human Elongin-B
{{PDB Gallery, geneid=6923