Edgar Douglas Adrian, 1st Baron Adrian (30 November 1889 – 4 August 1977) was an English electrophysiologist and recipient of the 1932 Nobel Prize for Physiology, won jointly with Sir Charles Sherrington for work on the function of

neuron A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural net ...

s. He provided experimental evidence for the all-or-none law of nerves.

Biography

Adrian was born in

Hampstead Hampstead () is an area in London, England, which lies northwest of Charing Cross, located mainly in the London Borough of Camden, with a small part in the London Borough of Barnet. It borders Highgate and Golders Green to the north, Belsiz ...

, London, the youngest son of Alfred Douglas Adrian, legal adviser to the

Local Government Board The Local Government Board (LGB) was a British Government supervisory body overseeing local administration in England and Wales from 1871 to 1919. The LGB was created by the Local Government Board Act 1871 ( 34 & 35 Vict. c. 70) and took over the ...

, and Flora Lavinia Barton. He was educated at

Westminster School Westminster School is a Public school (United Kingdom), public school in Westminster, London, England, in the precincts of Westminster Abbey. It descends from a charity school founded by Westminster Benedictines before the Norman Conquest, as do ...

and studied Natural Sciences at

Trinity College, Cambridge Trinity College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any ...

, graduating in 1911. In 1913 he was elected to a fellowship of Trinity College on account of his research into the "all or none" law of nerves. After completing a medical degree (MB BCh) in 1915, he undertook clinical work at

St Bartholomew's Hospital St Bartholomew's Hospital, commonly known as Barts, is a teaching hospital located in the City of London. It was founded in 1123 by Rahere, and is currently run by Barts Health NHS Trust. History Early history Barts was founded in 1123 by ...

London during

World War I World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to ...

, treating soldiers with nerve damage and nervous disorders such as shell shock. Adrian returned to Cambridge as a lecturer gaining his doctorate (MD) in 1919 and in 1925 began research on the human sensory organs by electrical methods.

Career

Continuing earlier studies of Keith Lucas, he used a capillary electrometer and

cathode-ray tube A cathode-ray tube (CRT) is a vacuum tube containing one or more electron guns, which emit electron beams that are manipulated to display images on a phosphorescent screen. The images may represent electrical waveforms on an oscilloscope, a ...

to amplify the signals produced by the

nervous system In biology, the nervous system is the complex system, highly complex part of an animal that coordinates its behavior, actions and sense, sensory information by transmitting action potential, signals to and from different parts of its body. Th ...

and was able to record the electrical discharge of single nerve fibres under physical stimulus. (It seems he used frogs in his experiments) An accidental discovery by Adrian in 1928 proved the presence of electricity within nerve cells. Adrian said,

I had arranged electrodes on the optic nerve of a toad in connection with some experiments on the retina. The room was nearly dark and I was puzzled to hear repeated noises in the loudspeaker attached to the amplifier, noises indicating that a great deal of impulse activity was going on. It was not until I compared the noises with my own movements around the room that I realised I was in the field of vision of the toad's eye and that it was signalling what I was doing.

A key result, published in 1928, stated that the excitation of the skin under constant stimulus is initially strong but gradually decreases over time, whereas the sensory impulses passing along the nerves from the point of contact are constant in strength, yet are reduced in frequency over time, and the sensation in the brain diminishes as a result. Extending these results to the study of pain causes by the stimulus of the nervous system, he made discoveries about the reception of such signals in the brain and spatial distribution of the sensory areas of the

cerebral cortex The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. It is the largest site of Neuron, neural integration in the central nervous system, and plays ...

in different animals. These conclusions lead to the idea of a sensory map, called the

homunculus A homunculus ( , , ; "little person", : homunculi , , ) is a small human being. Popularized in 16th-century alchemy and 19th-century fiction, it has historically referred to the creation of a miniature, fully formed human. The concept has root ...

, in the

somatosensory system The somatosensory system, or somatic sensory system is a subset of the sensory nervous system. The main functions of the somatosensory system are the perception of external stimuli, the perception of internal stimuli, and the regulation of bod ...

. Later, Adrian used the

electroencephalogram Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The bio signals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in the neoc ...

to study the electrical activity of the brain in humans. His work on the abnormalities of the

Berger Berger is a surname in both German language, German and French language, French, although there is no etymological connection between the names in the two languages. The French surname is an occupational name for a shepherd, from Old French ''bergi ...

rhythm paved the way for subsequent investigation in

epilepsy Epilepsy is a group of Non-communicable disease, non-communicable Neurological disorder, neurological disorders characterized by a tendency for recurrent, unprovoked Seizure, seizures. A seizure is a sudden burst of abnormal electrical activit ...

and other cerebral pathologies. He spent the last portion of his research career investigating

olfaction The sense of smell, or olfaction, is the special sense through which smells (or odors) are perceived. The sense of smell has many functions, including detecting desirable foods, hazards, and pheromones, and plays a role in taste. In humans, ...

. Positions that he held during his career included Foulerton Professor 1929–1937; Professor of Physiology in the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

1937–1951;

President of the Royal Society The president of the Royal Society (PRS), also known as the Royal Society of London, is the elected Head of the Royal Society who presides over meetings of the society's council. After an informal meeting (a lecture) by Christopher Wren at Gres ...

1950–1955; Master of

, 1951–1965; president of the

Royal Society of Medicine The Royal Society of Medicine (RSM) is a medical society based at 1 Wimpole Street, London, UK. It is a registered charity, with admission through membership. Its Chief Executive is Michele Acton. History The Royal Society of Medicine (R ...

1960–1962; Chancellor of the University of Cambridge 1967–1975; Chancellor of the

University of Leicester The University of Leicester ( ) is a public university, public research university based in Leicester, England. The main campus is south of the city centre, adjacent to Victoria Park, Leicester, Victoria Park. The university's predecessor, Univ ...

1957–1971. Adrian was elected a Foreign Honorary Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

and the

American Philosophical Society The American Philosophical Society (APS) is an American scholarly organization and learned society founded in 1743 in Philadelphia that promotes knowledge in the humanities and natural sciences through research, professional meetings, publicat ...

in 1938. He was elected an International Member of the United States

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

in 1941. In 1946 he became foreign member of the

Royal Netherlands Academy of Arts and Sciences The Royal Netherlands Academy of Arts and Sciences (, KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed in the Trippenhuis in Amsterdam. In addition to various advisory a ...

. In 1942 he was awarded the

Order of Merit The Order of Merit () is an order of merit for the Commonwealth realms, recognising distinguished service in the armed forces, science, art, literature, or the promotion of culture. Established in 1902 by Edward VII, admission into the order r ...

and in the 1955 New Year Honours was created Baron Adrian of Cambridge in the County of Cambridge.

Family

On 14 June 1923 Edgar Adrian married Hester Agnes Pinsent, who was the daughter of Ellen Pinsent and sister of David Pinsent. Together they had three children, first a daughter and then twins: * Anne Pinsent Adrian, who married the physiologist Richard Keynes, who was the great-grandson of

Charles Darwin Charles Robert Darwin ( ; 12 February 1809 – 19 April 1882) was an English Natural history#Before 1900, naturalist, geologist, and biologist, widely known for his contributions to evolutionary biology. His proposition that all speci ...

. The couple had four children. ** Adrian Keynes (1946–1974) ** Randal Keynes (*1948) ** Roger Keynes (*1951) **

Simon Keynes Simon Douglas Keynes ( ; born 23 September 1952) is a British historian who is Elrington and Bosworth Professor of Anglo-Saxon emeritus in the Department of Anglo-Saxon, Norse, and Celtic at the University of Cambridge, and a fellow of Trini ...

(*1952) * Richard Adrian, 2nd Baron Adrian (1927–1995) ** The couple had no children. * Jennet Adrian (b. 1927), who married Peter Watson Campbell ** Further family details unknown.

Bibliography

*''The Basis of Sensation'' (1928) *''The Mechanism of Nervous Action'' (1932) *''Factors Determining Human Behavior'' (1937)

Arms

References

External links

* including the Nobel Lecture on 12 December 1932 ''The Activity of the Nerve Fibres''
The Master of Trinity
at

{{DEFAULTSORT:Adrian, Edgar Douglas Adrian, 1st Baron 1889 births 1977 deaths People from Hampstead Alumni of the Medical College of St Bartholomew's Hospital Alumni of Trinity College, Cambridge 1 Hereditary barons created by Elizabeth II English neuroscientists English physiologists Chancellors of the University of Cambridge English Nobel laureates Masters of Trinity College, Cambridge Members of the Order of Merit Nobel laureates in Physiology or Medicine People educated at Westminster School, London People associated with the University of Leicester Presidents of the Royal Society Presidents of the Royal Society of Medicine Fellows of the Royal Society Recipients of the Copley Medal Royal Medal winners Honorary Fellows of the Royal Society of Edinburgh Fellows of the American Academy of Arts and Sciences Foreign associates of the National Academy of Sciences Members of the Royal Netherlands Academy of Arts and Sciences Vice-chancellors of the University of Cambridge Professors of Physiology (Cambridge) Members of the Royal Swedish Academy of Sciences International members of the American Philosophical Society