Ed Harlow
   HOME

TheInfoList



OR:

Ed Harlow (born 1952) is an American molecular biologist. Harlow received the Ph.D. degree from the Imperial Cancer Research Fund Laboratories in London. Harlow is professor of Biological Chemistry and Molecular Pharmacology at
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
. He has been associate director of the
Dana–Farber Cancer Institute Dana–Farber Cancer Institute (DFCI) is a comprehensive cancer treatment and research center in Boston, Massachusetts. Dana-Farber is the founding member of the Dana-Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated ...
as well as research director of the
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvar ...
Cancer Center and the
National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...
. From 2009 to 2011 he was Chief Scientific Officer at Constellation Pharmaceuticals. Among Harlow's discoveries was the demonstration that the
retinoblastoma protein Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye. It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cas ...
interacts with viral transforming proteins, thereby linking tumor viruses with the cell cycle. He is also the author, with David Lane, of "Using antibodies: a laboratory manual." (1999). Dr. Harlow has trained scientists in the field of molecular biology and oncology, including Nicholas Dyson (Professor at
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
and Scientific Director of the
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvar ...
Cancer Center), Jacqueline Lees (Professor of Biology at
MIT The Massachusetts Institute of Technology (MIT) is a private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and sc ...
and associate director of the Koch Institute), Joshua LaBaer (Virginia G. Piper Chair in Personalized Medicine at
Arizona State University Arizona State University (Arizona State or ASU) is a public university, public research university in Tempe, Arizona, United States. Founded in 1885 as Territorial Normal School by the 13th Arizona Territorial Legislature, the university is o ...
and Director of the Biodesign Institute), Matthew Meyerson (Professor of Pathology at the
Dana–Farber Cancer Institute Dana–Farber Cancer Institute (DFCI) is a comprehensive cancer treatment and research center in Boston, Massachusetts. Dana-Farber is the founding member of the Dana-Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated ...
and
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
and Senior Associate Member of the
Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institu ...
), Li-Huei Tsai (Picower Professor of Neuroscience at
MIT The Massachusetts Institute of Technology (MIT) is a private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and sc ...
and Director of the Picower Center for Learning and Memory), and Marc Vidal (Director of the Center for Cancer Systems Biology at the
Dana–Farber Cancer Institute Dana–Farber Cancer Institute (DFCI) is a comprehensive cancer treatment and research center in Boston, Massachusetts. Dana-Farber is the founding member of the Dana-Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated ...
).


Publications

*Dyson, Nicholas, et al. "The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product." Science 243.4893 (1989): 934–937. *Whyte, Peter, et al. "Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product." (1988): 124–129. *LaBaer, Joshua, et al. "New functional activities for the p21 family of CDK inhibitors." Genes & development 11.7 (1997): 847–862. *Buchkovich, Karen, Linda A. Duffy, and Ed Harlow. "The retinoblastoma protein is phosphorylated during specific phases of the cell cycle." Cell 58.6 (1989): 1097–1105. *van den Heuvel, Sander, and Ed Harlow. "Distinct roles for cyclin-dependent kinases in cell cycle control." Science 262.5142 (1993): 2050–2054. *Harlow, E. D., et al. "Monoclonal antibodies specific for simian virus 40 tumor antigens." Journal of Virology 39.3 (1981): 861–869. *Tsai, Li-Huei, et al. "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5." (1994): 419–423. *Meyerson, Matthew, et al. "A family of human cdc2-related protein kinases." The EMBO Journal 11.8 (1992): 2909. *Whyte, Peter, Nicola M. Williamson, and E. D. Harlow. "Cellular targets for transformation by the adenovirus E1A proteins." cell 56.1 (1989): 67–75.


Awards

*
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
, Member * Alfred P. Sloan, Jr. Prize *
American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...
, Member * Dickson Prize in Medicine *
National Academy of Medicine The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineerin ...
, Member *
American Cancer Society The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and '' Cancer Cytopathology''. History The society w ...
, Medal of Honor


References

{{DEFAULTSORT:Harlow, Ed 1952 births Living people American molecular biologists Harvard Medical School faculty Members of the National Academy of Medicine