Protein C-ETS2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''ETS2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
The
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
encoded by this gene belongs to the
ETS family of transcription factors.
It has been found to play a key role in the development of
inflammatory bowel disease
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. Crohn's disease affects the small intestine and large intestine ...
.
Interactions
ETS2 has been shown to
interact with:
*
C-jun,
[
* Cyclin-dependent kinase 10,]ERG
The erg is a unit of energy equal to 10−7joules (100Nano-, nJ). It is not an SI unit, instead originating from the centimetre–gram–second system of units (CGS). Its name is derived from (), a Greek language, Greek word meaning 'work' or ' ...
,
Clinical significance
ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. Crohn's disease affects the small intestine and large intestine ...
, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22.
References
Further reading
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External links
''Drosophila'' ''pointed'' - The Interactive Fly
{{Transcription factors, g3
Transcription factors