ERDRP-0519 is an

antiviral drug Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Antiviral drugs are a class of antimicrobials ...

which is the first drug specifically developed to target the

measles Measles (probably from Middle Dutch or Middle High German ''masel(e)'', meaning "blemish, blood blister") is a highly contagious, Vaccine-preventable diseases, vaccine-preventable infectious disease caused by Measles morbillivirus, measles v ...

morbillivirus. It acts as an inhibitor of the viral enzyme

RNA polymerase In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that catalyzes the chemical reactions that synthesize RNA from a DNA template. Using the e ...

which is essential for viral replication, and in animal studies showed good oral bioavailability and protected

ferret The ferret (''Mustela furo'') is a small, domesticated species belonging to the family Mustelidae. The ferret is most likely a domesticated form of the wild European polecat (''Mustela putorius''), as evidenced by the ferret's ability to inter ...

s from otherwise lethal doses of a morbillivirus when administered up to three days after infection.

History

The research was done at

Georgia State University Georgia State University (Georgia State, State, or GSU) is a Public university, public research university in Atlanta, Georgia, United States. Founded in 1913, it is one of the University System of Georgia's four research universities. It is al ...

and the

Paul Ehrlich Institute The Paul Ehrlich Institute (German: ''Paul-Ehrlich-Institut – Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel'', PEI) is a German Federal agency (Germany), federal agency, medical regulatory body and research institution for vacc ...

References

Experimental antiviral drugs Trifluoromethyl compounds Pyrazoles Sulfonamides 4-Morpholinyl compounds Anilides Piperidines {{antiinfective-drug-stub

History

See also

References