ERB-196, also known as WAY-202196, is a
synthetic nonsteroidal estrogen that acts as a highly
selective agonist of the
ERβ
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen. In humans ERβ is encoded by t ...
.
It possesses 78-fold selectivity for the ERβ over the
ERα.
The drug was under development by
Wyeth for the treatment of
inflammation and
sepsis starting in 2004 but development was discontinued by 2011.
See also
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8β-VE2
8β-VE2, or 8β-vinylestradiol, also known as 8β-vinylestra-1,3,5(10)-triene-3β,17β-diol, is a synthetic compound, synthetic estrogen (medication), estrogen featuring an estradiol (medication), estradiol core. It is a highly potency (pharmacol ...
*
Diarylpropionitrile
Diarylpropionitrile (DPN), also known as 2,3-bis(p-hydroxyphenyl)propionitrile (2,3-BHPPN), is a synthetic, nonsteroidal, and highly selective agonist of ERβ ( IC50 = 15 nM) that is used widely in scientific research to study the function of th ...
*
FERb 033
FERb 033 is a synthetic, nonsteroidal estrogen that was synthesized in 2009 and is used in scientific research. It is a potent and selective ERβ agonist (Ki = 7.1 nM, EC50 = 4.8 nM), with 62-fold selectivity for the ERβ over the ERα ...
*
Prinaberel
Prinaberel (International Nonproprietary Name, INN, United States Adopted Name, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic compound, synthetic, nonsteroidal, and highly binding selectivity, selective agonist of the estrog ...
*
WAY-166818
WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research. It acts as a highly selective full agonist of the ERβ, with 57- and 164-fold selectivity for the ERβ over the ERα in the rat and mouse ...
*
WAY-200070
WAY-200070 is a synthetic compound, synthetic, nonsteroidal, highly binding selectivity, selective agonist of ERβ. It possesses 68-fold selectivity for ERβ over ERα (EC50, EC50 = 2 nM and 155 nM, respectively). WAY-200070 has been found to enh ...
*
WAY-214156
WAY-214156 is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ. It is 100-fold selective for the ERβ over the ERα with an IC50 of 4.2 nM (compare to estradiol with IC50 values of ~3–4 nM for bo ...
References
External links
ERB-196 - AdisInsight
Hydroxyarenes
Fluoroarenes
Naphthalenes
Nitriles
Selective ERβ agonists
Synthetic estrogens
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