Eukaryotic translation initiation factor 4B is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''EIF4B''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Interactions
eIF4B has been shown to
interact with and stimulate the activity of
eIF4A
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of Messenger RNA, mRNA to 40S ribosome, ribosomal subunits. In addition these prot ...
and bind to the
eIF3
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. It is essential for most forms of Eukaryotic translation#Cap-dependent initiation, cap-dependent and Eukaryotic ...
complex through the
eIF3A
Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the ''EIF3A'' gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translati ...
subunit.
This interaction results in the recruitment of the
eukaryotic small ribosomal subunit (40S)
The eukaryotic small ribosomal subunit (40S) is the smaller subunit of the 80S, eukaryotic 80S ribosomes, with the other major component being the eukaryotic large ribosomal subunit (60S), large ribosomal subunit (60S). The "40S" and "60S" names o ...
to the mRNA which will in turn set the stage for the later steps leading to
elongation.
See also
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Eukaryotic translation
Eukaryotic translation is the biological process by which messenger RNA is Translation (biology), translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recapping.
Initiation
Translation init ...
*
eIF4F
Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the Five-prime cap, 5' cap of Messenger RNA, messenger RNAs (mRNAs) to promote eukaryotic translation initiation. The eIF4F complex is composed of three non-i ...
References
Further reading
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