Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''EIF3K''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The ~800 kDa
eukaryotic initiation factor 3
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. It is essential for most forms of cap-dependent and cap-independent translation initiation. In humans, eIF3 co ...
(eIF3) is the largest
eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the
40S ribosomal subunit and promoting formation of the
43S preinitiation complex.
Interactions
eIF3k has been shown to
interact with
Cyclin D3 and
eIF3a.
See also
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Eukaryotic initiation factor 3 (eIF3)
References
Further reading
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External links
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