Eukaryotic translation initiation factor 2-alpha kinase 4 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''EIF2AK4''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
EIF2AK4 belongs to a family of kinases that
phosphorylate
In biochemistry, phosphorylation is described as the "transfer of a phosphate group" from a donor to an acceptor. A common phosphorylating agent (phosphate donor) is ATP and a common family of acceptor are alcohols:
:
This equation can be writt ...
the alpha subunit of eukaryotic translation initiation factor-2 (
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the ''EIF2S1'' gene.
Function
The protein encoded by this gene is the alpha (α) subunit of the translation initiation factor eIF2 prote ...
; MIM 603907) to downregulate
protein synthesis
Protein biosynthesis, or protein synthesis, is a core biological process, occurring inside cells, balancing the loss of cellular proteins (via degradation or export) through the production of new proteins. Proteins perform a number of critica ...
in response to varied cellular stresses (Berlanga et al., 1999).
upplied by OMIMref name="entrez"/>
See also
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Gcn2
References
Further reading
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External links
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EC 2.7.11
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