Eukaryotic translation initiation factor 2A (eIF2A) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''EIF2A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
The eIF2A protein is not to be confused with
eIF2α, a subunit of the heterotrimeric
eIF2
Eukaryotic Initiation Factor 2 (eIF2) is a eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer ...
complex. Instead, eIF2A functions by a separate mechanism in
eukaryotic translation.
Function
eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).
upplied by OMIMref name="entrez"> It may be important for translation initiation mediated by the
HCV IRES under stress conditions, but this result has been debated.
References
Further reading
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