Endothelium-derived relaxing factor (EDRF) is a name for a

substance Substance may refer to: * Matter, anything that has mass and takes up space Chemistry * Chemical substance, a material with a definite chemical composition * Drug substance ** Substance abuse, drug-related healthcare and social policy diagnosis o ...

that

Robert F. Furchgott Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was a Nobel Prize-winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems. Early life and education Furchgott ...

discovered had the eponymous properties. Today, it is firmly established this substance is

nitric oxide Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its ...

(NO).

Endothelium The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the ve ...

produces NO which then diffuses to the vascular smooth muscle tissue, although there seems to be evidence that vasodilation may also be of neuronal origin, rather than endothelial. NO is produced by the enzyme

nitric oxide synthase Nitric oxide synthases () (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and per ...

and it relaxes

smooth muscle tissue Smooth muscle is an involuntary non- striated muscle, so-called because it has no sarcomeres and therefore no striations (''bands'' or ''stripes''). It is divided into two subgroups, single-unit and multiunit smooth muscle. Within single-unit m ...

by promoting the synthesis of

cGMP CGMP is an initialism. It can refer to: *cyclic guanosine monophosphate (cGMP) *current good manufacturing practice (cGMP) *CGMP, Cisco Group Management Protocol, the Cisco version of Internet Group Management Protocol The Internet Group Managem ...

. Furchgott was a co-recipient of the 1998

Nobel Prize in Medicine The Nobel Prize in Physiology or Medicine ( sv, Nobelpriset i fysiologi eller medicin) is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or ...

with his colleagues

Louis J. Ignarro Louis J. Ignarro (born May 31, 1941) is an American pharmacologist. For demonstrating the signaling properties of nitric oxide, he was co-recipient of the 1998 Nobel Prize in Physiology or Medicine with Robert F. Furchgott and Ferid Murad. ...

and

Ferid Murad Ferid Murad (born September 14, 1936) is an American physician and pharmacologist, and a co-winner of the 1998 Nobel Prize in Physiology or Medicine. Early life Murad was born in Whiting, Indiana. His parents were Henrietta Josephine Bowm ...

. Shortly after his death in May 2009, Furchgott's website at

SUNY Downstate Medical Center SUNY Downstate Health Sciences University (Downstate) is a public medical school and hospital in Brooklyn, New York. It is the southernmost member of the State University of New York (SUNY) system and the only academic medical center for health e ...

continued to state that his group was "investigating whether the endothelium-derived relaxing factor (EDRF) is simply nitric oxide or a mixture of substances".

References

External links

* * * Nitrogen compounds Nitrogen cycle {{biology-stub