E-6801 is a
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given Receptor (biochemistry), receptor, but have only partial Intrinsic activity, efficacy at the receptor relative to a full agonist. They may also be considered Ligand (bio ...
of the
5-HT6 receptor.
It enhanced recognition memory and reversed the memory deficits of
scopolamine
Scopolamine, also known as hyoscine, or Devil's Breath, is a medication used to treat motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva. When used by injection, effects begin a ...
in an object recognition task in a rat model.
The mechanism of memory enhancement is due to a combined modulation of
cholinergic
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. In general, the word " choline" describes the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation ...
and
glutamatergic
Glutamatergic means "related to glutamate". A glutamatergic agent (or drug) is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. Examples include excitatory amino acid receptor agonist ...
neurotransmission.
See also
*
E-6837
E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication.
In cell lines expressing rat 5-HT6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist ...
References
{{Tryptamines
5-HT6 agonists
Anorectics
Chloroarenes
N,N-Dialkyltryptamines
Imidazothiazoles
Sulfonamides