Drugwipe Test
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The DrugWipe is a test used to wipe surfaces for traces of drug residue. It may also be used for sweat or saliva testing of individuals. DrugWipe was named a finalist in the 2011 Cygnus Law Enforcement Group Innovation Awards competition. The DrugWipe 6s (saliva only) test was entered under the category of 'Traffic Enforcement'.


Operation

The DrugWipe is a moist wipe used to detect drug residue on surfaces, or on the forehead, palm, or tongue of an individual. An integrated ampule is broken, which is the medium for transporting the collected analyte to the antigen-binding site. The DrugWipe can be configured to detect
cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species be ...
,
cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...
,
opiates An opiate is an alkaloid substance derived from opium (or poppy straw). It differs from the similar term ''opioid'' in that the latter is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain ( ...
,
amphetamine Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, an ...
s,
MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used ...
, and
benzodiazepine Benzodiazepines (BZD, BDZ, BZs), colloquially known as "benzos", are a class of central nervous system (CNS) depressant, depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed t ...
s.
Immunoassay An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoassay ...
strips containing
antibodies An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that caus ...
bind to components of the different drugs.


Reliability

A number of independent studies examine the efficacy of the DrugWipe, particularly for its lack of sensitivity for detecting Cannabis (
delta-9-thc Tetrahydrocannabinol (THC) is a cannabinoid found in cannabis. It is the principal psychoactive constituent of ''Cannabis'' and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) de ...
) which the Australian National Health Survey 2009 listed as the most frequently used illicit drug at 10.4% with 36% smoking at least once a week or more in 2016. Independent field testing of the DrugWipe in Finland recorded a high rate of false negatives, particularly for Cannabis, this is where a person tests negative however had recently used 14.4%. including the sensitivity of less than 50%. According to statistics by the National Institute for Health and Welfare in Finland, of positive results for cannabis, cocaine, and opioids, two-thirds were false compared to blood samples. As positive test results have been used as sufficient grounds for a ban on driving, the Finnish Parliamentary Ombudsman issued a statement condemning the practice. THC in the saliva is said to be an index of recent cannabis smoking and closely linked to the effects of intoxication however in another study, volunteers were recruited to consume cannabis and subsequent levels of THC taken from saliva. The amounts detected were only above the level of the DrugWipe at 10 ng/ml for 70 minutes, with volunteers reporting feeling intoxicated for a further 2 hours. As this 1999 DEA Bulletin shows, Drugwipe is still effective when testing '
black cocaine Black cocaine () is a mixture of regular cocaine base or cocaine hydrochloride with various other substances. These other substances are added * to camouflage the typical appearance (pigments and dyes, e.g. charcoal), * to interfere with color ...
' even when chemical tests fail to detect it. "At three checkpoints organized by the Swiss police in Bern, 61 drivers were tested for the presence of drugs of abuse using the Drugwipe 5 device. In parallel, oral fluid was collected with the Intercept DOA Oral Specimen Collection device and tested by gas chromatography-mass spectrometry (GC-MS) after methylation of THC (limit of quantitation 1 ng/mL) The Drugwipe device identified 1 exposed driver, but with GC-MS, 18 drivers tested positive. THC concentrations in the Intercept buffer ranged from 2.1 to 205.1 ng/mL. These concentrations represent about 1/2 to 1/3 the authentic THC concentrations in oral fluid because of the dilution by the blue liquid of the device. Two main limitations of oral fluid were 1. the amount of matrix collected is smaller when compared to urine, and 2. the levels of drugs in urine are higher than in oral fluid. A current limitation of the use of this specimen for roadside testing is the absence of a suitable immunoassay that detects the parent compound in sufficiently low concentrations." "The three tested on-site screening devices, Mavand RapidSTAT®, Securetec Drugwipe-5+® and Dräger DrugTest 5000® were able to detect about 70% of all cocaine and cannabis users in a roadside setting. Amphetamine/MDMA users were detected more easily, with a sensitivity higher than 92%. The sensitivity of oral fluid screening tests for THC is increasing as manufacturers are still trying to lower the cut-off of their devices. First results using the new DrugTest 5000 test cassette® demonstrate that a sensitivity of 93% is possible." "During a 11-month period, 1.212 drivers were tested. Both OF and on-site urine tests were compared to serum results. The following sensitivities were obtained by the oral fluid devices: THC 71% (DrugWipe(®)), 87% (Dräger), 91% (RapidSTAT); opiates 95% (Dräger), 100% (DrugWipe(®), RapidSTAT(®)); amphetamine 84% (DrugTest(®) 5000), 90% (RapidSTAT(®)), 100% (DrugTest(®) 5000); methamphetamine 50% (DrugTest(®) 5000), 100% (RapidSTAT(®)); cocaine 76% (DrugTest(®) 5000), 100% (DrugWipe(®), RapidSTAT(®)); methadone 33-63%, and benzodiazepines 0-33% (both with a low number of positives). THC specificity was especially low (29% rugWipe(®)and 47% rugTest(®) 5000 due to low cut-off concentrations. These data were similar to those obtained from the literature (e.g., DRUID project)." Drugwipe tests from saliva used by Finnish police have been found to be unreliable. According to statistics by the National Institute for Health and Welfare in Finland, of positive results for cannabis, cocaine and opioids, two-thirds were false compared to a blood test. As positive test results have been used as sufficient grounds for a ban on driving, the Finnish Parliamentary Ombudsman issued a statement condemning the practice.


References


External links


DrugWipe article co-authored by product company and Lycoming County Probation Dept.

National Institute of Justice (U.S. Dept. of Justice)'s Guide for Drug Detectors for Law Enforcement
{{DEFAULTSORT:Drugwipe Test Drug control law Chemical tests