enzymology An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

, a dolichyl-phosphate beta-D-mannosyltransferase () is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

that

catalyzes Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...

the

chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...

:GDP-mannose + dolichyl phosphate

\rightleftharpoons

GDP + dolichyl D-mannosyl phosphate Thus, the two substrates of this enzyme are

GDP-mannose Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. This compound is a substrate for enzymes called mannosyltransferases. Known as donor of activated mannose in a ...

and

dolichyl phosphate Dolichol monophosphate is a phosphate ester of dolichol. See also * Dolichyl-phosphatase * Dolichyl-phosphate beta-D-mannosyltransferase * DPM1 Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the ''DPM1'' gene. ...

, whereas its two

products Product may refer to: Business * Product (business), an item that can be offered to a market to satisfy the desire or need of a customer. * Product (project management), a deliverable or set of deliverables that contribute to a business solution ...

are

GDP Gross domestic product (GDP) is a monetary measure of the total market value of all the final goods and services produced and rendered in a specific time period by a country or countries. GDP is often used to measure the economic performance o ...

and dolichyl D-mannosyl phosphate. This enzyme belongs to the family of

glycosyltransferase Glycosyltransferases (GTFs, Gtfs) are enzymes ( EC 2.4) that establish natural glycosidic linkages. They catalyze the transfer of saccharide moieties from an activated nucleotide sugar (also known as the "glycosyl donor") to a nucleophilic gl ...

s, specifically the hexosyltransferases. The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...

of this enzyme class is GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase. Other names in common use include GDP-Man:DolP mannosyltransferase, dolichyl mannosyl phosphate synthase, dolichyl-phospho-mannose synthase, GDP-mannose:dolichyl-phosphate mannosyltransferase, guanosine diphosphomannose-dolichol phosphate mannosyltransferase, dolichol phosphate mannose synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, GDP-mannose-dolichol phosphate mannosyltransferase, GDP-mannose-dolichylmonophosphate mannosyltransferase, mannosylphosphodolichol synthase, and mannosylphosphoryldolichol synthase. This enzyme participates in n-glycan biosynthesis.

References

* * * * * EC 2.4.1 Enzymes of unknown structure {{2.4-enzyme-stub