Dock4-Ex49 is a splice variant of the signalling protein

Dock4 Dock4, (Dedicator of cytokinesis 4) also known as DOCK4, is a large (~190 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which ...

(Dedicator of cytokinesis 4). It has been found in the brain,

inner ear The inner ear (internal ear, auris interna) is the innermost part of the vertebrate ear. In vertebrates, the inner ear is mainly responsible for sound detection and balance. In mammals, it consists of the bony labyrinth, a hollow cavity in the ...

and

eye Eyes are organs of the visual system. They provide living organisms with vision, the ability to receive and process visual detail, as well as enabling several photo response functions that are independent of vision. Eyes detect light and conv ...

. It is able to bind and activate the small G protein

Rac RAC or Rac may refer to: Organizations * Radio Amateurs of Canada * RATCH-Australia Corporation, electricity generator * Refugee Action Collective (Victoria), Melbourne, Australia * Religious Action Center of Reform Judaism, US * Rent-A-Center, ...

and may regulate the organisation of the actin cytoskeleton in the Stereocilia of the inner ear.

References

{{reflist Genes on human chromosome 7