Diverted total synthesis in

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...

is a strategy in

drug discovery In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or ...

aiming at

organic synthesis Organic synthesis is a branch of chemical synthesis concerned with the construction of organic compounds. Organic compounds are molecules consisting of combinations of covalently-linked hydrogen, carbon, oxygen, and nitrogen atoms. Within the gen ...

natural product A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical s ...

analogues rather than the natural product itself. The target can be the modification of a natural product or the modification of an intermediate. In this sense it differs from other strategies such as

total synthesis Total synthesis, a specialized area within organic chemistry, focuses on constructing complex organic compounds, especially those found in nature, using laboratory methods. It often involves synthesizing natural products from basic, commercially ...

and

semisynthesis Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbiology, microbial cell cultures or plant material) as the starting materials to produce novel ...

. The purpose can be gaining a scientific understanding of the

biological activity In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or ...

of the original natural product or the discovery of new drugs with the same biological activity but simpler to produce. The concept was introduced by Samuel J. Danishefsky in 2006. Notable examples of this strategy are the potential drug

ixabepilone Ixabepilone ( INN; also known as azaepothilone B, codenamed BMS-247550) is a pharmaceutical drug developed by Bristol-Myers Squibb as a chemotherapeutic medication for cancer. History Ixabepilone is a semi-synthetic analog of epothilone B, a ...

which is an analogue of the natural product epothilone B and

carfilzomib Carfilzomib, sold under the brand name Kyprolis, is an anti-cancer medication acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It was developed by Onyx Pharmaceuticals. The U ...

which is derived from epoxomicin and eravacycline derived from

tetracycline Tetracycline, sold under various brand names, is an antibiotic in the tetracyclines family of medications, used to treat a number of infections, including acne, cholera, brucellosis, plague, malaria, and syphilis. It is available in oral an ...

Cabergoline Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications. It is taken by mouth. Cabergoline is an ...

is derived from a number of

ergot alkaloids Ergot ( ) or ergot fungi refers to a group of fungus, fungi of the genus ''Claviceps''. The most prominent member of this group is ''Claviceps purpurea'' ("rye ergot fungus"). This fungus grows on rye and related plants, and produces alkaloids ...

one of which is

lysergic acid Lysergic acid, also known as -lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of '' Argyreia nervosa'' ( Hawaiian baby woodrose), and ''Ipomo ...

and

Simvastatin Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease hyperlipidemia, elevated lipid levels. It is also used to decrease t ...

is based on

Lovastatin Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease. Its use is recommended together with lifestyle changes. It is taken by mouth. ...

. Diverted total synthesis is a topic in academic research.

References

{{reflist, colwidth=60em , refs= ''Design and synthesis of analogues of natural products'' Martin E. Maiera Org. Biomol. Chem., 2015,13, 5302-5343 {{doi, 10.1039/C5OB00169B ''Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection'' Rebecca M. Wilson‡ and Samuel J. Danishefsky*,‡,§ The Journal of Organic Chemistry 2006 71 (22), 8329-8351 {{doi, 10.1021/jo0610053 Fürstner, A. (2011), ''From Total Synthesis to Diverted Total Synthesis: Case Studies in the Amphidinolide Series''. Isr. J. Chem., 51: 329–345. {{doi, 10.1002/ijch.201100006 ''Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties'' Alois Fürstner, Douglas Kirk, Michaël D. B. Fenster, Christophe Aïssa, Dominic De Souza, and Oliver Müller PNAS vol. 102 no. 23 8103–8108 2005, {{doi, 10.1073/pnas.0501441102 Lei, X. and Danishefsky, Samuel J. (2008), ''Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition''. Adv. Synth. Catal., 350: 1677–1681. {{doi, 10.1002/adsc.200800187 ''Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog'' Thordur Oskarsson, Pavel Nagorny, Isaac J. Krauss, Lucy Perez, Mihirbaran Mandal, Guangli Yang, Ouathek Ouerfelli, Danhua Xiao, Malcolm A. S. Moore, Joan Massagué, and Samuel J. Danishefsky Journal of the American Chemical Society 2010 132 (9), 3224-3228 {{doi, 10.1021/ja9101503 ''Synthetic studies toward (+)-cortistatin'' A Zhang Wang, Mingji Dai, Peter K. Park Samuel J. Danishefsky Tetrahedron Volume 67, Issue 52, 30 December 2011, Pages 10249–10260 {{doi, 10.1016/j.tet.2011.10.026 ''Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity'' Paul A. Wender, Jeremy L. Baryza, Stacey E. Brenner, Brian A. DeChristopher, Brian A. Loy, Adam J. Schrier, and Vishal A. Verma Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17): 6721–6726. {{doi, 10.1073/pnas.1015270108 ''Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin'' Nicolas Lecomte, Jon T. Njardarson, Pavel Nagorny, Guangli Yang, Robert Downey, Ouathek Ouerfelli, Malcolm A. S. Moore, and Samuel J. Danishefsky Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37): 15074-15078 {{doi, 10.1073/pnas.1015247108 ''Nickel-catalyzed regiodivergent approach to macrolide motifs'' Abdur-Rafay Shareef, David H. Sherman and John Montgomery Chem. Sci., 2012,3, 892-895 {{doi, 10.1039/C2SC00866A ''Nitroso Diels-Alder (NDA) Reaction as an Efficient Tool for the Functionalization of Diene-Containing Natural Products'' Serena Carosso and Marvin J. Miller Org Biomol Chem. 2014 Oct 14; 12(38): 7445–7468 {{doi, 10.1039/c4ob01033g ''Counting on natural products for drug design'' Tiago Rodrigues, Daniel Reker, Petra Schneider & Gisbert Schneider Nature Chemistry 8, 531–541 (2016) {{doi, 10.1038/nchem.2479 Total synthesis