Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
that in humans is encoded by the FDPS gene and
catalyzes the
transformation of
dimethylallylpyrophosphate (DMAPP) and
isopentenyl pyrophosphate (IPP) into
farnesylpyrophosphate (FPP).
Pyrophosphate
In chemistry, pyrophosphates are phosphorus oxyanions that contain two phosphorus atoms in a P–O–P linkage. A number of pyrophosphate salts exist, such as disodium pyrophosphate (Na2H2P2O7) and tetrasodium pyrophosphate (Na4P2O7), among o ...
is also involved, as both a
reactant
In chemistry, a reagent ( ) or analytical reagent is a substance or compound added to a system to cause a chemical reaction, or test if one occurs. The terms ''reactant'' and ''reagent'' are often used interchangeably, but reactant specifies a ...
and a
product.
Geranylpyrophosphate
Geranyl pyrophosphate (GPP), also known as geranyl diphosphate (GDP), is the pyrophosphate ester of the terpenoid geraniol. Its salts are colorless. It is a precursor to many natural products.
Occurrence
GPP is an intermediate in the isoprenoid ...
is created in an intermediate step.
See also
*
Geranyltranstransferase
In enzymology, a geranyltranstransferase () is an enzyme that catalyzes the chemical reaction
:geranyl diphosphate + isopentenyl diphosphate \rightleftharpoons diphosphate + trans,trans-farnesyl diphosphate
Thus, the two substrates of this enzym ...
References
External links
*
*
EC 2.5.1
{{2.5-enzyme-stub