Difemetorex (
INN; sold as Cleofil), also known as diphemethoxidine, is a
stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...
drug
A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...
of the
piperidine class which was used as an
appetite suppressant, but produced intolerable
side effects such as
insomnia which limited its clinical use.
It was introduced in
France by
Ciba-Geigy in 1966 but is now no longer marketed.
Synthesis

Alkylation of desoxypipradrol with ethyleneoxide gives difemetorex.
See also
*
Desoxypipradrol
Desoxypipradrol, also known as 2-diphenylmethylpiperidine (2-DPMP), is a drug developed by Ciba in the 1950s which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI).
Chemistry
Desoxypipradrol is closely related on a structural lev ...
*
Diphenylprolinol
*
SCH-5472
SCH-5472. is a stimulant drug developed by Schering-Plough in the 1950s. Synthesis
Potassium amide was made from the reaction of potassium metal with liquid ammonia. The coupling between the carbanion created from diphenylmethane 01-81-5(1) a ...
References
{{Monoamine reuptake inhibitors
Primary alcohols
Anorectics
Norepinephrine–dopamine reuptake inhibitors
2-Benzylpiperidines
Stimulants
Abandoned drugs