combination drug
A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. Terms like "combination drug" or "combination drug product" can be common shorthand for a FDC pr ...
composed of sodium amobarbital (previously called amylbarbitone and its brand name Amytal) and
dextroamphetamine sulfate
Dextroamphetamine is a central nervous system (CNS) stimulant and an amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance and ...
(Dexedrine) within the same pill. It was widely abused, and is no longer manufactured.
First introduced in 1950 by Smith, Kline & French (SKF), Dexamyl was marketed as an
anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic.
The term is (from the Greek ''ἀν-'' (an-) = "without" ...
obesity medication as well as an
anxiolytic
An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxie ...
and
antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness ...
medication that did not cause agitation.
Racemic
In chemistry, a racemic mixture, or racemate (), is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt. Racemic mixtures are rare in nature, but many compounds are produced industrially as racemates. ...
decongestant
A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract. The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter ...
inhaler
An inhaler (also known as a puffer, pump or allergy spray) is a medical device used for delivering medicines into the lungs through the work of a person's breathing. This allows medicines to be delivered to and absorbed in the lungs, which prov ...
device under the brand name
Benzedrine
Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used a ...
, and also as an oral tablet since 1938. Dexamyl utilized its
enantiopure
In chemistry, an enantiomer ( /ɪˈnænti.əmər, ɛ-, -oʊ-/ ''ih-NAN-tee-ə-mər''; from Ancient Greek ἐνάντιος ''(enántios)'' 'opposite', and μέρος ''(méros)'' 'part') – also called optical isomer, antipode, or optical anti ...
isomer of greater central nervous system (CNS) selectivity, dextroamphetamine sulfate, to elevate mood and suppress appetite, whereas the concomitant
barbiturate
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as ...
was included to broadly counteract potential adverse effects from dextroamphetamine. Its name is a
abuse liability
Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods which are harmful to the individual or others. It is a form of substance-related disorder. Differing definitions of drug abuse are used in public health, ...
which characterized long-term Dexamyl usage.
History
British prime minister
Anthony Eden
Robert Anthony Eden, 1st Earl of Avon, (12 June 1897 – 14 January 1977) was a British Conservative Party politician who served as Prime Minister of the United Kingdom from 1955 until his resignation in 1957.
Achieving rapid pro ...
was prescribed Dexamyl; he was using it to treat abdominal pain. It has been suggested that the drug impaired his judgment during the
Suez Crisis
The Suez Crisis, or the Second Arab–Israeli war, also called the Tripartite Aggression ( ar, العدوان الثلاثي, Al-ʿUdwān aṯ-Ṯulāṯiyy) in the Arab world and the Sinai War in Israel,Also known as the Suez War or 1956 Wa ...
. The failure of his Suez policies led to his ousting while he was recovering in
Jamaica
Jamaica (; ) is an island country situated in the Caribbean Sea. Spanning in area, it is the third-largest island of the Greater Antilles and the Caribbean (after Cuba and Hispaniola). Jamaica lies about south of Cuba, and west of Hispan ...
.
In Britain during the early 1960s the drug was taken by "tired housewives", and was also abused by youths who took excessively large doses and nicknamed the triangular blue tablets "purple hearts" or "blues." This became a celebrated part of the Mod subculture. Dexamyl was the recreational drug of choice for main character of the film ''
Quadrophenia
''Quadrophenia'' is the sixth studio album by the English rock band the Who, released as a double album on 26 October 1973 by Track Records. It is the group's third rock opera, the two previous being the "mini-opera" song "A Quick One, Whi ...
'', who eventually suffers from amphetamine psychosis. They were widely abused.
In the late 1960s and early 1970s, Dexamyl spansules—a clear and green capsule containing green and white "beads"—became popular as a street-drug upper nicknamed "Christmas trees", a reference to its appearance.
In his autobiography ''My Life of Absurdity'', author Chester Himes writes of his use of Dexamyl in the mid-1950s. He also writes that he stopped taking the drug after his friend Vandi Haygood died from "steady doses of Dexamyl".
Dr. George C. Nichopoulos was indicted in May 1980 for having improperly prescribed Dexamyl and
phenmetrazine
Phenmetrazine (INN, USAN, BAN) (brand name Preludin, and many others) is a stimulant drug first synthesized in 1952 and originally used as an appetite suppressant, but withdrawn from the market in the 1980s due to widespread abuse. It was initia ...
(Preludin) to the singer
Jerry Lee Lewis
Jerry Lee Lewis (September 29, 1935October 28, 2022) was an American singer, songwriter and pianist. Nicknamed "The Killer", he was described as " rock & roll's first great wild man". A pioneer of rock and roll and rockabilly music, Lewis mad ...
, despite knowing he was addicted to them.
Dr. Patrick A. Mazza, team physician for the
Reading Phillies
Reading is the process of taking in the sense or meaning of letters, symbols, etc., especially by sight or touch.
For educators and researchers, reading is a multifaceted process involving such areas as word recognition, orthography (spelling) ...
Dexedrine
Dextroamphetamine is a central nervous system (CNS) stimulant and an amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance and co ...
, and Preludin for
Steve Carlton
Steven Norman Carlton (born December 22, 1944) is an American former professional baseball player. He played in Major League Baseball as a left-handed pitcher for six different teams from 1965 to 1988, most notably as a member of the Philadelphi ...
Tim McCarver
James Timothy McCarver (born October 16, 1941) is an American former professional baseball player and television sports commentator. He played in Major League Baseball as a catcher from to , most prominently as a member of the St. Louis Cardin ...
,
Pete Rose
Peter Edward Rose Sr. (born April 14, 1941), also known by his nickname "Charlie Hustle", is an American former professional baseball player and manager. Rose played in Major League Baseball (MLB) from 1963 to 1986, most prominently as a membe ...
,
Larry Bowa
Lawrence Robert Bowa (born December 6, 1945) is an American former professional baseball shortstop, manager, and coach in Major League Baseball (MLB), who played for the Philadelphia Phillies, Chicago Cubs, and New York Mets. Bowa went on to man ...
, and Greg Luzinski. The charges against Mazza were dropped after he contended that he had provided the prescriptions in good faith to the baseball players at their request. The pill was writer
Terry Southern
Terry Southern (May 1, 1924 – October 29, 1995) was an American novelist, essayist, screenwriter, and university lecturer, noted for his distinctive satirical style. Part of the Paris postwar literary movement in the 1950s and a companion to ...
's drug of choice for many years.{{cite news , url=http://www.oxfordamerican.org/item/784-nights-of-terror-days-of-weird, title=Nights of Terror, Days of Weird , last=Stephenson , first=Will , date=March 22, 2016 , work=Oxford American , access-date=2018-04-25 , language=en-gb
See also
* Amfecloral, a single molecule with a similar effect (due to metabolites).
* Desbutal, another pharmaceutical containing an amphetamine and a barbiturate.
* D-IX, an experimental drug containing methamphetamine, cocaine & oxycodone.
* The song " Big Black Smoke" by
the Kinks
The Kinks were an English rock band formed in Muswell Hill, north London, in 1963 by brothers Ray and Dave Davies. They are regarded as one of the most influential rock bands of the 1960s. The band emerged during the height of British rhyt ...
makes reference to the drug with the lyric "And every penny she had was spent on purple hearts and cigarettes."
*
Dexy's Midnight Runners
Dexys Midnight Runners (currently officially Dexys, their former nickname, styled without an apostrophe) are an English pop rock band from Birmingham, with soul influences, who achieved major commercial success in the early to mid-1980s. They a ...