Deoxyadenosine (symbol dA or dAdo) is a
deoxyribonucleoside
A deoxyribonucleotide is a nucleotide that contains deoxyribose. They are the monomeric units of the informational biopolymer, deoxyribonucleic acid (DNA). Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), a nitr ...
. It is a
derivative
In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...
of the
nucleoside adenosine
Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9- glycosidic bond. Adenosine is one of the four nucleoside build ...
, differing from the latter by the replacement of a
hydroxyl group (-OH) by hydrogen (-H) at the
2′ position of its
ribose
Ribose is a simple sugar and carbohydrate with molecular formula C5H10O5 and the linear-form composition H−(C=O)−(CHOH)4−H. The naturally occurring form, , is a component of the ribonucleotides from which RNA is built, and so this comp ...
sugar
moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with
deoxythymidine (T) in double-stranded DNA.
In absence of
adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (
ADA-SCID).
See also
*
Deoxyribonucleotide
A deoxyribonucleotide is a nucleotide that contains deoxyribose. They are the monomeric units of the informational biopolymer, deoxyribonucleic acid (DNA). Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), a ni ...
*
Cordycepin (3′-deoxyadenosine)
*
Severe combined immunodeficiency
References
Nucleosides
Purines
Hydroxymethyl compounds
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