Demodex Folliculorum

''Demodex folliculorum'' is a microscopic mite that can survive only on the skin of humans. Most people host ''D.folliculorum'' on their skin particularly on the face, where sebaceous glands are most concentrated. Usually, the mites do not cause any harm, so are considered an example of commensalism rather than parasitism; but they can cause disease, known as demodicosis.

Anatomy

Due to being adapted to live inside hair follicles, ''D. folliculorum'' is thin and worm-like, with short legs. As an adult, ''D.folliculorum'' measures long. Adults have four pairs of legs; larvae and nymphs have only three pairs. ''D.folliculorum'' has a rudimentary gut but lacks an anus, so waste accumulates within the body until it dies.

Reproduction and life cycle

The entire life cycle of ''D.folliculorum'' takes 14–16 days. Adult mites copulate at the top of the hair follicle, near the skin surface. Eggs are deposited in the sebaceous gland inside the hair follicle. The heart-shaped egg is long, and hatches into a six-legged larva. In seven days the larva develops into a mature adult, with two intervening nymph stages. The adult lives for four to six days.

Ecology

''D. folliculorum'' prefers areas where sebum production is high, and is typically found in hair follicles on the human face, generally in greater numbers around the cheeks, nose, and forehead, but also elsewhere on the face, eyelids, and ears. The mites may also be found on other parts of the body, such as the chest and buttocks.

Within the hair follicle, ''D. folliculorum'' is found above the sebaceous gland, positioned head downward, with the end of the abdomen often protruding from the hair follicle. Inhabited follicles usually contain 2–6 mites, but numbers can be greater.

In one hour, ''D. folliculorum'' can travel ; they usually travel at night.

The mites are obligate commensals of humans, and can live only on the skin; they soon dry out and die if they leave the host. Higher numbers of ''D.folliculorum'' are found in the spring and summer than at other times of year.

Relationship with humans

''D. folliculorum'' is not found on newborn babies, but is acquired shortly after birth, most likely from maternal contact. Few mites are found on children under 10 years of age, but nearly all elderly people have them. The increasing population over time may be due to a small initial presence gradually growing over time, or may be because levels of the mite's food, sebum, increase with age.

High numbers of ''D. folliculorum'' are associated with blepharitis and acne rosacea. The mechanism by which the mites cause disease is unknown; they may physically block the hair follicle, carry disease-causing bacteria or, after death, their bodies may cause either a delayed hypersensitivity response, or an innate immune response. Controversy exists over whether high numbers of ''D. folliculorum'' cause rosacea, or whether the skin environment caused by rosacea is more hospitable to mites than normal skin, allowing them to flourish. Populations of ''D. folliculorum'' are higher in people with immunosuppression.

History

The first report of ''Demodex folliculorum'' was made by German scientist Jakob Henle in 1841, but his presentation to the Natural Sciences Society of Zurich, reported in a local newspaper, attracted little attention at the time.

In 1842, German dermatologist Gustav Simon was investigating the formation of acne pustules and blackheads using hair follicle samples under a microscope, when he noticed movement within the sample. He described himself as surprised to find a tiny "head, legs, fore and hind body" pressed between the two glass plates of the sample, and was then able to replicate his discovery with other samples. Simon gave a full report of the appearance of ''D. folliculorum'', naming it ''Acarus folliculorum''.

The following year, 1843, the genus was named ''Demodex'' by English scientist Richard Owen. From Simon's initial description of ''D.folliculorum'' onwards, two forms were recognized, a long form and a short form. In 1963, it was suggested by LK Akbulatova that these long and short forms were two subspecies of ''D.folliculorum'', and that the smaller mite be named '' Demodex brevis'', with the larger mite retaining the name ''D. folliculorum''. It was not until 1972 that the existence of two separate species was confirmed.

See also

* Human microbiome

References

External links

*

{{Taxonbar, from=Q4171774

Trombidiformes
Animals described in 1842
Parasitic_arthropods_of_humans