Deborah Carmen Mash is an American professor of

neurology Neurology (from , "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine) , medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous syst ...

and of

molecular A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemistry, ...

and cellular

pharmacology Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur betwee ...

at the

Miller School of Medicine The University of Miami Miller School of Medicine, officially Leonard M. Miller School of Medicine, is the University of Miami's graduate medical school in Miami, Florida. Founded in 1952, it is the oldest medical school in the state of Florida. ...

and director of the Brain Endowment Bank at the

University of Miami The University of Miami (UM, UMiami, Miami, U of M, and The U) is a private university, private research university in Coral Gables, Florida, United States. , the university enrolled 19,852 students in two colleges and ten schools across over ...

. She is also the Chief Executive Officer and founder of DemeRx.

Early research

Mash became fascinated with the

human brain The human brain is the central organ (anatomy), organ of the nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activi ...

while she was an undergraduate student at

Florida State University Florida State University (FSU or Florida State) is a Public university, public research university in Tallahassee, Florida, United States. It is a senior member of the State University System of Florida and a preeminent university in the s ...

. After completing a

Bachelor of Arts A Bachelor of Arts (abbreviated B.A., BA, A.B. or AB; from the Latin ', ', or ') is the holder of a bachelor's degree awarded for an undergraduate program in the liberal arts, or, in some cases, other disciplines. A Bachelor of Arts deg ...

degree there, she completed a Ph.D. program at the

at the

, and did a

postdoctoral A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary acade ...

fellowship A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned or professional societies, the term refers ...

Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...

's Beth Israel Hospital in

Boston Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...

, Massachusetts. In 1986, she joined the faculty of her ''alma mater'', the University of Miami.

Ibogaine

In 1994, the

Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...

of the United States granted Mash an

Investigational New Drug The United States Food and Drug Administration's Investigational New Drug (IND) program is the means by which a pharmaceutical industry, pharmaceutical company obtains permission to start human clinical trials and to ship an experimental drug inte ...

license, to permit her to research the addiction-stopping capabilities of

ibogaine Ibogaine is a psychoactive indole alkaloid derived from plants such as '' Tabernanthe iboga'', characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research ...

(an

oneirogen An oneirogen, from the Greek ὄνειρος ''óneiros'' meaning "dream" and ''gen'' "to create", is a substance that induces a dream-like state of consciousness. Oneirogens function by altering neural processing in a way that shifts the brain ...

that occurs in some plants). A lack of funding and other barriers prevented the research from proceeding. Mash and her colleagues had previously discovered that ibogaine is a

prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be ...

that metabolizes into a

psychoactive A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, psychoactive substance, or psychotropic substance is a chemical substance that alters psychological functioning by modulating central nervous system acti ...

called 12-hydroxyibogamine (or,

noribogaine Noribogaine (actually ''O''-desmethylibogaine), or 12-hydroxyibogamine, is the principal psychoactive metabolite of the oneirogen ibogaine. It is thought to be involved in the antiaddictive effects of ibogaine-containing plant extracts, such as ...

). In the late 1990s she provided some assistance to Healing Transitions Institute for Addiction, a

drug detoxification Drug detoxification (informally, detox) is variously construed or interpreted as a type of "medical" intervention or technique in regards to a physical dependence mediated by a drug; as well as the process and experience of a withdrawal syndrome ...

clinic in

Cancún Cancún is the most populous city in the Mexican state of Quintana Roo, located in southeast Mexico on the northeast coast of the Yucatán Peninsula. It is a significant tourist destination in Mexico and the seat of the municipality of Benito J ...

where physicians oversaw patients' ibogaine treatments.

TASER International

On eight occasions between 2005 and 2009, she served as an

expert witness An expert witness, particularly in common law countries such as the United Kingdom, Australia, and the United States, is a person whose opinion by virtue of education, training, certification, skills or experience, is accepted by the judge as ...

for the defense in

wrongful death claim Wrongful death is a type of legal claim or cause of action against a person who can be held liable for a death. The claim is brought in a civil action, usually by close relatives, as authorized by statute. In wrongful death cases, survivors are ...

s filed against

electroshock weapon An electroshock weapon is an incapacitating weapon. It delivers an electric shock aimed at temporarily disrupting muscle functions and/or inflicting pain, usually without causing significant injury. Many types of these devices exist. Stun guns, b ...

manufacturer

TASER International Axon Enterprise, Inc. (formerly TASER International) is an American company based in Scottsdale, Arizona, that develops technology and weapons products for military, law enforcement, and civilians. Its initial product and former namesake is the ...

. Mash was paid by the company to testify on its behalf, prompting some criticism of a conflict of interest. The company's official position was that the

cause of death In law, medicine, and statistics, cause of death is an official determination of the conditions resulting in a human's death, which may be recorded on a death certificate. A cause of death is determined by a medical examiner. In rare cases, an ...

Taser Taser (stylized in all caps) is a line of handheld conducted energy devices (CED) sold by Axon Enterprise (formerly Taser International). The device fires two small barbed darts intended to puncture the skin and remain attached to the targe ...

fatalities was

excited delirium Excited delirium (ExDS), also known as agitated delirium (AgDS) or hyperactive delirium syndrome with severe agitation, is a widely rejected pseudoscientific diagnosis characterized as a potentially fatal state of extreme agitation and delirium ...

. Excited delirium, a syndrome not recognized by many medical associations including

World Health Organization The World Health Organization (WHO) is a list of specialized agencies of the United Nations, specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Gen ...

American Psychiatric Association The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world. It has more than 39,200 members who are in ...

, and

American Medical Association The American Medical Association (AMA) is an American professional association and lobbying group of physicians and medical students. This medical association was founded in 1847 and is headquartered in Chicago, Illinois. Membership was 271,660 ...

is not included in the

International Classification of Diseases The International Classification of Diseases (ICD) is a globally used medical classification that is used in epidemiology, health management and clinical diagnosis. The ICD is maintained by the World Health Organization (WHO), which is the dir ...

or the

Diagnostic and Statistical Manual of Mental Disorders The ''Diagnostic and Statistical Manual of Mental Disorders'' (''DSM''; latest edition: ''DSM-5-TR'', published in March 2022) is a publication by the American Psychiatric Association (APA) for the classification of mental disorders using a com ...

. Mash performed

post-mortem examination An autopsy (also referred to as post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death; ...

s of the brains of people who were allegedly victims of excited delirium, and reported that most of them showed signs of

drug abuse Substance misuse, also known as drug misuse or, in older vernacular, substance abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others. It is a form of substance-related disorder, differing definitions ...

—most frequently

cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...

amphetamine Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, an ...

References

External links

* * {{DEFAULTSORT:Mash, Deborah Living people American neurologists American women neurologists American women neuroscientists American neuroscientists Florida State University alumni Harvard Medical School people Ibogaine activists American pharmacologists American women pharmacologists Leonard M. Miller School of Medicine alumni University of Miami faculty Place of birth missing (living people) 1952 births American women academics 21st-century American women scientists 21st-century American scientists

Early research

Ibogaine

TASER International

References

Further reading

External links