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Mass General Brigham (MGB) (formerly Partners HealthCare) is a
not-for-profit A not-for-profit or non-for-profit organization (NFPO) is a Legal Entity, legal entity that does not distribute surplus funds to its members and is formed to fulfill specific objectives. While not-for-profit organizations and Nonprofit organ ...
, integrated
health care Health care, or healthcare, is the improvement or maintenance of health via the preventive healthcare, prevention, diagnosis, therapy, treatment, wikt:amelioration, amelioration or cure of disease, illness, injury, and other disability, physic ...
system that engages in
medical research Medical research (or biomedical research), also known as health research, refers to the process of using scientific methods with the aim to produce knowledge about human diseases, the prevention and treatment of illness, and the promotion of ...
, teaching, and patient care. It is the largest hospital-based research enterprise in the United States, with annual funding of more than $2 billion. The system's annual revenue was $20.6 billion in 2024. It is also an educational institution, founded by
Brigham and Women's Hospital Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...
and
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvar ...
. The system provides clinical care through two academic hospitals, three specialty hospitals, seven
community hospital A community hospital can be purely a nominal designation or have a more specific meaning. When specific, it refers to a hospital that is accessible to the general public and provides a general or specific medical care which is usually short-term, i ...
s,
home care Homecare (home care, in-home care, care at home), also known as domiciliary care, personal care, community care, or social care, is health care or supportive care provided in the individual home where the patient or client is living, generally focu ...
services, a
health insurance Health insurance or medical insurance (also known as medical aid in South Africa) is a type of insurance that covers the whole or a part of the risk of a person incurring medical expenses. As with other types of insurance, risk is shared among ma ...
plan, and a robust network of specialty practices,
urgent care An urgent care center (UCC), also known as an urgent treatment centre (UTC) in the United Kingdom, is a type of walk-in clinic focused on the delivery of urgent ambulatory care in a dedicated medical facility outside of a traditional emergency depa ...
facilities, and outpatient clinics/surgical centers. It is the largest private employer in
Massachusetts Massachusetts ( ; ), officially the Commonwealth of Massachusetts, is a U.S. state, state in the New England region of the Northeastern United States. It borders the Atlantic Ocean and the Gulf of Maine to its east, Connecticut and Rhode ...
.


History

Mass General Brigham was founded by the academic medical centers (AMCs) which give it its name:
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is a teaching hospital located in the West End neighborhood of Boston, Massachusetts. It is the original and largest clinical education and research facility of Harvard Medical School/Harvar ...
(colloquially referred to as "Mass General") and
Brigham and Women's Hospital Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...
("the Brigham"). Both hospitals were founded in the early 1800s, are based in
Boston Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...
, and serve as major
teaching hospitals A teaching hospital or university hospital is a hospital or medical center that provides medical education and training to future and current health professionals. Teaching hospitals are almost always affiliated with one or more universities ...
of
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
. In 1994, fueled by economic and political pressure to cut costs on patient care and health care education, the two hospitals merged to create a new parent
corporation A corporation or body corporate is an individual or a group of people, such as an association or company, that has been authorized by the State (polity), state to act as a single entity (a legal entity recognized by private and public law as ...
: Partners HealthCare. The two entities continued to operate largely independently, and remained competitors in multiple areas, until 2019. In 2015, Partners launched an
electronic health record An electronic health record (EHR) is the systematized collection of electronically stored patient and population health information in a digital format. These records can be shared across different health care settings. Records are shared thro ...
(EHR) system, allowing doctors, nurses, and other caregivers easier access patients'
medical history The medical history, case history, or anamnesis (from Greek: ἀνά, ''aná'', "open", and μνήσις, ''mnesis'', "memory") of a patient is a set of information the physicians collect over medical interviews. It involves the patient, and ev ...
. The effort computerized millions of
health records The terms medical record, health record and medical chart are used somewhat interchangeably to describe the systematic documentation of a single patient's medical history and care across time within one particular health care provider's jurisdict ...
across the system, creating one record for each Partners patient, allowing information to be more easily shared among caregivers. In 2016, the system moved to into their current headquarters, located in
Somerville Somerville may refer to: Places Australia *Somerville, Victoria, a town **Somerville railway station * Somerville, Western Australia, a suburb of Kalgoorlie, Australia New Zealand * Somerville, New Zealand, a suburb of Manukau City, New Zea ...
's
Assembly Row Assembly Square is a neighborhood in Somerville, Massachusetts, United States. It is located along the west bank of the Mystic River, bordered by Ten Hills and Massachusetts Route 28 to the north and the Charlestown neighborhood of Boston t ...
. The building allowed Mass General Brigham to merge 14 other offices. In 2019, 25 years after the founding of Partners, the health system made the decision to fully integrate the organization under the new name "Mass General Brigham". Mass General Brigham has 2.5 million
patients A patient is any recipient of health care services that are performed by healthcare professionals. The patient is most often ill or injured and in need of treatment by a physician, nurse, optometrist, dentist, veterinarian, or other healt ...
annually, generating $18 billion in operating revenue and more than $2 billion in research funding. Brigham and Women's and Massachusetts General are consistently ranked among the best hospitals in
America The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...
, while
Massachusetts Eye and Ear Massachusetts Eye and Ear (Mass Eye and Ear, or MEE) is a specialty hospital located in Boston, Massachusetts, United States, which focuses on ophthalmology (eye), otolaryngology (ear/nose/throat), and related medicine and research. Founded in 18 ...
, McLean, and Spaulding are also among the nation's best in their respective specialties. Its current President and CEO is Dr. Anne Klibanski.


Board of Directors

The system's current Board of Directors consists of the following members: Executive Committee of the Board * Scott M. Sperling (chairman) – co-chief executive officer at Thomas H. Lee Partners * John Fish – CEO of Suffolk Construction Company *
Jonathan Kraft Jonathan Ashford Kraft (born March 4, 1964) is an American businessman. He is president of The Kraft Group, the holding company of the Kraft family's business interests. He is also the president of the New England Patriots and investor-operator ...
– president of The Kraft Group Board Members * Robert Atchinson – co-founder of Adage Capital Management * Marc Casper – chairman/president/CEO of Thermo Fisher Scientific * Yolonda Colson – chief for the Division of Thoracic Surgery at Massachusetts General Hospital * Zara Cooper – Brigham & Women's Hospital, assoc professor of Surgery at Harvard Medical School *
Anne Finucane Anne Finucane (born July 18, 1952) is an American banker who was the first female vice chair of Bank of America and chair of Bank of America Europe until retiring from the bank in 2021, and from her BofA Europe chair role at the end of 2022, afte ...
– vice chair of Bank of America, board chair of Bank of America Europe. * Benjamin Gomez – head of capital markets at BNP Paribas Real Estate Spain * Tiffany Gueye – senior advisor at Blue Meridian Partners *
Susan Hockfield Susan Hockfield (born March 24, 1951) is an American neuroscientist who served as the 16th president of the Massachusetts Institute of Technology from 2004 to 2012. Hockfield currently serves as a Professor of Neuroscience in MIT's Department ...
– professor of neuroscience and President Emerita at MIT * Albert A. Holman, III – founder and president of Chestnut Partners, Inc * David W. Ives – former chairman, Northshore International Insurance Services, Inc * Anne Klibanski, MD – president & CEO of Mass General Brigham * Carl J. Martignetti – president of Martignetti Companies *
Nitin Nohria Nitin Nohria (born February 9, 1962) is an Indian-American academic. He was the tenth dean of Harvard Business School. He is also the George F. Baker Professor of Administration. He is a former non-executive director of Tata Sons. In January 202 ...
– former dean of Harvard Business School * Diane B. Patrick – senior counsel at Ropes & Gray *
Phillip Ragon Phillip Terrence "Terry" Ragon is an American entrepreneur and philanthropist who founded InterSystems and is the current CEO. Early life and education The son of a U.S. Air Force fighter pilot, Ragon was born in Arizona. He grew up in a variet ...
–founder/owner/CEO of InterSystems Corporation * Pamela Reeve – former CEO and current chair of multiple publicly traded & non-profit companies * Paula Ness Speers – partner and managing director, Health Advances * James D. Taiclet – president & CEO of Lockheed Martin * Alexander L. Thorndike – president of Choate Investment Advisors * Carol Vallone – board chair at McLean Hospital, advisory director at Berkshire Partners


Composition

Current members of Mass General Brigham include:


Affiliated Organizations


Nobel Laureates

There are at least 22 Nobel Prize winners affiliated with Mass General Brigham institutions.


History of Firsts

The following is a lists of medical firsts and milestones accomplished by Mass General Brigham institutions: * 1811: Massachusetts General Hospital opens and becomes the first teaching hospital of
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
. * 1818: The Asylum for the Insane, a division of Mass General, opens as the first hospital in New England to treat
mental illness A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...
. In 1892, it is renamed
McLean Hospital McLean Hospital () (formerly known as Somerville Asylum and Charlestown Asylum) is a psychiatric hospital in Belmont, Massachusetts. McLean maintains the world's largest neuroscientific and psychiatric research program in a private hospital. It i ...
, which is known today as the flagship mental health hospital of Harvard Medical School and Mass General Brigham. * 1832: The Boston Lying-in Hospital was founded in Boston, MA, as one of the nation's first maternity hospitals dedicated to women unable to afford in-home medical care. It is the first of
Brigham and Women's Hospital Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...
predecessor institutions. * 1837: The first North American book on
tumors A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
was written by MGH co-founder Dr.
John Collins Warren John Warren may refer to: Entertainment * John F. Warren (1909–2000), American cinematographer * John Warren (actor) (1916–1977), British screenwriter and actor * John Warren (musician) (born 1938), Canadian baritone saxophonist and compos ...
. * 1841: MGH's Warren Library became the first general hospital library in the U.S. * 1846:
William T.G. Morton William Thomas Green Morton (August 9, 1819 – July 15, 1868) was an American dentist and physician who first publicly demonstrated the use of inhaled ether as a surgical anesthetic in 1846. He is credited with gaining the medical world’s accep ...
, MD, and John Collins Warren, MD, of Mass General perform the first successful public demonstration of surgical ether anesthesia. * 1846: The "first truly significant medical patent ever issued" was U.S. Patent No. 4848. It was given to Drs. Charles T. Jackson and William T. G. Morton for the discovery of sulfuric ether as a surgical
anesthetic An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness. They may be divided into t ...
. * 1847: MGH's Dr.
John Barnard Swett Jackson John Barnard Swett Jackson (June 5, 1806 – January 6, 1879) was an American surgeon and pathologist. He was the first curator of the Warren Anatomical Museum and was dean of Harvard Medical School from 1853 to 1855. In 1854, the Shattuck Prof ...
became the first professor of
pathology Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...
in the U.S. * 1870: MGH's Dr. James Clarke White opened the first ward in North America dedicated to
skin diseases A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this sys ...
; the following year, he became the first American professor of
dermatology Dermatology is the branch of medicine dealing with the Human skin, skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A List of dermatologists, ...
. * 1888: MGH opened the Bradlee Operating Theater, the first
aseptic Asepsis is the state of being free from disease-causing micro-organisms (such as pathogenic bacteria, viruses, pathogenic fungi, and parasites). There are two categories of asepsis: medical and surgical. The modern day notion of asepsis is deri ...
operating room in U.S. * 1896: Walter J. Dodd, an apothecary and photographer at MGH, produced the first X-ray exposure in a U.S. hospital. * 1900: Two 1878 graduates of the Massachusetts General Hospital Training School for Nurses, Sophia Palmer and Mary E. P. Davis, founded the
American Journal of Nursing The ''American Journal of Nursing'' (AJN) is a monthly peer-reviewed nursing journal established in 1900. the editor-in-chief is Carl Kirton and it is published by Lippincott Williams & Wilkins. In 2009 the journal was selected as one of the "10 ...
, the first independent nursing publication to be owned and operated by nurses. * 1905: Though MGH's Ida M. Cannon and Dr. Richard Cabot are credited with establishing the first
Social Service Social services are a range of public services intended to provide support and assistance towards particular groups, which commonly include the disadvantaged. Also available amachine-converted HTML They may be provided by individuals, private and i ...
department located within a hospital. * 1914: MGH physician Dr. Paul Dudley White introduced the use of the electrocardiogram (ECG) in the U.S. * 1914: A pioneering
allergy Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
clinic was instituted by MGH's Dr. Joseph L. Goodale, who was "the first to make a
skin test A skin test is a medical test in which a substance is injected into the skin. Examples * Casoni test * Corneometry * Dick test * Fernandez reaction * Frei test * Hair perforation test * Kveim test * Leishmanin skin test * Lepromin * Pat ...
with substances other than
pollen Pollen is a powdery substance produced by most types of flowers of seed plants for the purpose of sexual reproduction. It consists of pollen grains (highly reduced Gametophyte#Heterospory, microgametophytes), which produce male gametes (sperm ...
." * 1921: MGH physician Dr. Ernest Amory Codman founded the Registry of Bone Sarcoma, the first national registry of its kind in the U.S. * 1923: The first successful
heart valve A heart valve is a biological one-way valve that allows blood to flow in one direction through the chambers of the heart. A mammalian heart usually has four valves. Together, the valves determine the direction of blood flow through the heart. Hea ...
surgery in the world is performed at the Peter Bent Brigham Hospital by Elliot C. Cutler, MD. * 1926:
Harvey Cushing Harvey Williams Cushing (April 8, 1869 – October 7, 1939) was an American neurosurgery, neurosurgeon, pathologist, writer, and draftsman. A pioneer of brain surgery, he was the first exclusive neurosurgeon and the first person to describe Cush ...
, MD, performs the first surgery using an electrosurgical generator in an operating room at the Peter Bent Brigham Hospital. * 1929: The first
polio Poliomyelitis ( ), commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 75% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe ...
victim is saved using the newly developed
Drinker respirator An iron lung is a type of negative pressure ventilator, a mechanical respirator which encloses most of a person's body and varies the air pressure in the enclosed space to stimulate breathing. It assists breathing when muscle control is lost, ...
(iron lung) at the Peter Bent Brigham Hospital. * 1934: Under the leadership of Dr. Richard C. Cabot, MGH became the first hospital in the country to offer a pastoral care training program. * 1937: A man of many "firsts", MGH endocrinologist Dr.
Fuller Albright Fuller Albright (January 12, 1900 – December 8, 1969) was an American endocrinologist who made numerous contributions to his field, especially to the area of calcium metabolism. Albright made great strides and contributions to the understanding ...
described what came to be known as Albright Syndrome. * 1939: MGH's Dr. Edward D. Churchill, who performed the first successful
pericardiectomy Pericardiectomy is the surgical removal of part or most of the pericardium. This operation is most commonly used to relieve constrictive pericarditis, or to remove a pericardium that is calcified and fibrous. It may also be used for severe or re ...
in the United States, developed the technique of segmental resection of the lung for certain infections like
bronchiectasis Bronchiectasis is a disease in which there is permanent enlargement of parts of the bronchi, airways of the lung. Symptoms typically include a chronic cough with sputum, mucus production. Other symptoms include shortness of breath, hemoptysis, co ...
. * 1940: MGH's Ada Plumer became the first "official IV ntravenousnurse" in the U.S. Until that time, it had been a medical role. * 1942: MGH's Dr.
Saul Hertz Saul Hertz, M.D. (April 20, 1905 – July 28, 1950) was an American physician who devised the medical uses of radioactive iodine. Hertz pioneered the first targeted cancer therapies. Hertz is called the father of the field of theranostics, combini ...
and MIT physicist Dr. Arthur Roberts used
radioactive Radioactive decay (also known as nuclear decay, radioactivity, radioactive disintegration, or nuclear disintegration) is the process by which an unstable atomic nucleus loses energy by radiation. A material containing unstable nuclei is conside ...
iodine Iodine is a chemical element; it has symbol I and atomic number 53. The heaviest of the stable halogens, it exists at standard conditions as a semi-lustrous, non-metallic solid that melts to form a deep violet liquid at , and boils to a vi ...
for the first time as a therapeutic agent in the diagnosis and treatment of
Graves' disease Graves' disease, also known as toxic diffuse goiter or Basedow's disease, is an autoimmune disease that affects the thyroid. It frequently results in and is the most common cause of hyperthyroidism. It also often results in an enlarged thyro ...
, helping to usher in the field of
nuclear Nuclear may refer to: Physics Relating to the nucleus of the atom: *Nuclear engineering *Nuclear physics *Nuclear power *Nuclear reactor *Nuclear weapon *Nuclear medicine *Radiation therapy *Nuclear warfare Mathematics * Nuclear space *Nuclear ...
medicine. * 1949:
Carl Walter Carl Walter (c. 1831 – 7 October 1907), also known as Charles Walter, was an Australian botanist and photographer. He was born in Mecklenburg, Germany in about 1831 and arrived in Victoria in the 1850s. Botanical work Walter discovered and ...
, MD, invents and perfects a way to collect, store and transfuse blood at the Peter Bent Brigham Hospital. * 1954: The first successful human organ transplant, a kidney transplant, is accomplished at Peter Bent Brigham Hospital.
Joseph Murray Joseph Edward Murray (April 1, 1919 – November 26, 2012) was an American plastic surgeon who is known as the "father of transplantation" for major milestones in the field of transplantation, including performing the first successful human ki ...
, MD, receives the
Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
for this work. * 1955: Drs. Wilma Jeanne Canada and Leonard W. Cronkhite, Jr., both residents in radiology at MGH, were the first to recognize the syndrome that bears their name, Cronkhite–Canada Syndrome. * 1960:
Dwight Harken Dwight Emary Harken (1910–1993) was an American surgeon. He was an innovator in heart surgery and introduced the concept of the intensive care unit. Life Dwight Harken was born in Osceola, Iowa. He received his Bachelor's and Medical degrees ...
, MD inserts the first prosthetic aortic valve directly into a human heart at the site of the biological valve. He also implants the first "demand"
pacemaker A pacemaker, also known as an artificial cardiac pacemaker, is an implanted medical device that generates electrical pulses delivered by electrodes to one or more of the chambers of the heart. Each pulse causes the targeted chamber(s) to co ...
and pioneers the use of the first pacemakers at the Peter Bent Brigham Hospital. * 1962:
Joseph Murray Joseph Edward Murray (April 1, 1919 – November 26, 2012) was an American plastic surgeon who is known as the "father of transplantation" for major milestones in the field of transplantation, including performing the first successful human ki ...
, MD, performs the world's first successful
kidney transplantation Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with end-stage kidney disease (ESRD). Kidney transplant is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantat ...
from an unrelated
cadaver A cadaver, often known as a corpse, is a Death, dead human body. Cadavers are used by medical students, physicians and other scientists to study anatomy, identify disease sites, determine causes of death, and provide tissue (biology), tissue to ...
donor. The procedure included the first clinical use of the immunosuppressive drug
azathioprine Azathioprine, sold under the brand name Imuran, among others, is an immunosuppressive medication. It is used for the treatment of rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, and systemic lupus er ...
. * 1962: MGH's Dr.
Ronald Malt Ronald A. Malt (November 12, 1931 – October 5, 2002) was an American clinical surgeon and teacher at Massachusetts General Hospital (MGH) and Harvard Medical School for over 40 years. Born in Pittsburgh, Malt attended Washington University and H ...
and his team led the first successful limb replantation after twelve-year-old Everett "Red" Knowles's arm had been severed in an accident. * 1963: MGH's Dr. Charles Huggins helped revolutionize blood bank procedures through his invention of the cytoglomerator, enabling freezing and storing
red blood cells Red blood cells (RBCs), referred to as erythrocytes (, with -''cyte'' translated as 'cell' in modern usage) in academia and medical publishing, also known as red cells, erythroid cells, and rarely haematids, are the most common type of blood cel ...
for extended periods. * 1968: The first telemedicine system, which linked a medical station at Boston's
Logan Airport General Edward Lawrence Logan International Airport — also known as Boston Logan International Airport — is an international airport located mostly in East Boston and partially in Winthrop, Massachusetts, United States. Covering , it has ...
with doctors at MGH, was established. * 1969: Considered the "father of modern-day tracheal surgery" in the United States, MGH's Dr.
Hermes Grillo Hermes C. Grillo (1923–2006) was a world-famous thoracic surgeon and professor of surgery at Harvard Medical School. He was born in Boston in 1923 and died at age 83 in a car accident in Italy on October 14, 2006. He is considered the father of ...
developed original operations for disorders that were once considered uncorrectable. * 1971: Three MGH physicians: Drs. Howard Ulfelder, Arthur L. Herbst and David C. Poskanzer, were the first to discover the link between the vaginal clear cell
adenocarcinoma Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ; AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ...
and the drug DES (
diethylstilbestrol Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. In the past, it was widely used for a variety of indications, including pregnancy support for those with ...
), at one time prescribed to prevent miscarriages. * 1974: MGH dermatologists Drs. Thomas Fitzpatrick and John Parrish introduced the field of
photochemotherapy Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT is used in treating acne, wet age-related macular ...
to treat skin disorders such as
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...
. * 1976: Brigham and Women's Hospital researchers launch the Nurses' Health Study, enrolling 122,000 women in America's first and largest women's health study. * 1978: MGH's Dr. Jeffrey B. Cooper, with colleagues at MGH and MIT, developed the "Boston Anesthesia System," the first
anesthesia Anesthesia (American English) or anaesthesia (British English) is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prev ...
machine engineered by way of human-factors studies, and the first with computer-based operations. * 1981: Faulker Hospital makes history by being the first to successfully transfuse a patient with "rejuvenated blood". * 1981: MGH surgeon Dr. John F. Burke, along with Dr. Ioannis V. Yannas, from the
Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...
's department of mechanical engineering, invented the first commercially reproducible, synthetic human skin. * 1983: MGH neurogeneticist Dr. James Gusella lead a team that found a genetic marker for
Huntington's disease Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly Genetic disorder#Autosomal dominant, inherited. It typically presents as a triad of progressive psychiatric, cognitive, and ...
. * 1983: Dr. Allan Goroll, a pioneer of modern primary care, collaborated with his MGH colleagues on the first textbook in that field. * 1989: MGH became the first hospital in the U.S. whose library had an online catalog * 1991: Dr. Jack Belliveau, researcher in MGH's Athinoula A. Martinos Center for
Biomedical Imaging Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to revea ...
, reported the first demonstration of functional
MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and rad ...
(fMRI). * 1995: The Brigham performs the nation's first triple
organ transplant Organ transplantation is a medical procedure in which an organ (anatomy), organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or org ...
, removing three organs from a single donor—two lungs and a heart—and transplanting them into three patients. * 1999: MGH's Dr. Thomas Spitzer and colleagues reported on the first-ever organ transplant carried out with the intention of stopping antirejection therapy. * 2000: In what is believed to be a first in organ transplantation, the Brigham performs a quadruple transplant, harvesting four organs from a single donor—a kidney, two lungs and a heart—and transplanting them into four patients. * 2004: The Brigham performs the nation's first implant of the new Intrinsic dual-chamber
implantable cardioverter-defibrillator An implantable cardioverter-defibrillator (ICD) or automated implantable cardioverter defibrillator (AICD) is a device implantable inside the body, able to perform defibrillation, and depending on the type, cardioversion and pacing of the h ...
(ICD). * 2007: MGH surgeons performed the first total
hip replacement Hip replacement is a surgery, surgical procedure in which the hip joint is replaced by a prosthetic implant (medicine), implant, that is, a hip prosthesis. Hip replacement surgery can be performed as a total replacement or a hemi/semi(half) repl ...
using a joint socket lined with a novel material invented at MGH. * 2009: Brigham surgeons complete the second partial facial transplant in the United States. * 2011: A multidisciplinary team at Brigham and Women's Hospital, led by Bohdan Pomahac, MD, performs the first full-
face transplant A face transplant is a medical procedure to replace all or part of a person's face using tissue from a donor. Part of a field called "Vascularized Composite Tissue Allotransplantation" (VCA) it involves the transplantation of facial skin, the n ...
in the U.S. * 2015: An international team led by MGH researchers identified the first gene that causes
mitral valve prolapse Mitral valve prolapse (MVP) is a valvular heart disease characterized by the displacement of an abnormally thickened mitral valve leaflet into the atria of the heart, left atrium during Systole (medicine), systole. It is the primary form of myxom ...
. * 2016: The Brigham performs the first bilateral arm transplant on a patient injured during military service. * 2016: MGH was the first hospital in the country where a
liver transplant Liver transplantation or hepatic transplantation is the replacement of a Liver disease, diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for Cirrhosis, end-stage liver disease and ...
was performed using what doctors loosely call "liver in a box", a portable device. * 2016: A surgical team led by MGHers Drs. Curtis L. Cetrulo, Jr. and Dicken S.C. Ko performed the country's first genitourinary vascularized composite allograft (penile) transplant. * 2017: MGH's Dr. Bradley E. Bernstein, along with colleagues from MGH, Mass. Eye and Ear, and the
Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institu ...
at MIT, created the first atlas of head and neck cancer.


Innovations and ventures

Mass General Brigham is the largest hospital system-based research enterprise in America, with an annual research budget exceeding $2 billion. It is the top system for
National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
(NIH) funding in the world, receiving $1.04 billion from NIH in 2022. The system's funding for research has grown from $1.5 billion in 2012 to $2.3 billion in 2023, with nearly 2/3 of the funds coming from outside of Massachusetts. Research revenues in 2022 were $2.2 billion. In 2023, the system said it had over 2,700 ongoing
clinical trials Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...
, focused on accelerating new treatments and therapies. Among the system's recent innovations:
Visudyne Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degen ...
for
macular degeneration Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred vision, blurred or vision loss, no vision in the center of the visual field. Early on there are often no sym ...
,
Enbrel Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. I ...
for
rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects synovial joint, joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and h ...
, Eloctate and Alprolix for hemophilia, Entyvio for
crohn's disease Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the ...
, and total joint replacements such as Durasul, Longevity, E1, and Vicacit-E.


Expansion and influence

In May 2000, CEO Dr. Samuel Thier and William C. Van Faasen, CEO of Blue Cross Blue Shield of Massachusetts—the state's biggest health insurer—agreed to a deal that raised insurance costs all across Massachusetts. They agreed that Van Faasen would substantially increase insurance payments to Mass General Brigham doctors and hospitals, largely correcting the underpayments of the previous 10 years. However, Partners issued a statement saying that Thier pledged only that he would treat all insurers equally. According to Boston Globe investigative journalists, Blue Cross and other insurers increased the rate they paid Mass General Brigham by 75 percent between 2000 and 2008, though CEO James J. Mongan argued insurance rates in Massachusetts have gone up at roughly the same rate as the national average. In 2013, Mass General Brigham's plan to take over 378-bed South Shore Hospital in Weymouth was reviewed due to fears that the expansion plan is anticompetitive, a conduct Mass General Brigham had been accused of over the past four years in other cases. In 2015, the system abandoned their plans to invest $200 million into the hospital. In April 2017, the United States District Court for the District of Massachusetts announced that Partners HealthCare System and one of its hospitals, Brigham and Women's Hospital, agreed to pay a $10 million fine to resolve allegations that a stem cell research lab fraudulently obtained federal grant funding. Federal prosecutors commended the Brigham for disclosing allegations of fraudulent research at the lab and for taking steps to prevent future recurrences of such conduct. In May 2017, Partners announced they would be cutting more than $600 million in expenses over the next three years in an effort to control higher costs and to become more efficient. The cost-cutting initiative was called Partners 2.0, and the plan looked to reduce costs in research, care delivery, revenue collection, and supply chain. The plan began on October 1, 2017 and eliminated jobs. The company lost $108 million in 2016, but was profitable in 2017 despite industry turmoil. In February 2018, Partners announced that 100 coders would have their jobs outsourced to India in a cost saving move. This was all part of the non-profit hospital and physicians network's three-year plan to reduce $500 million to $800 million in overhead costs. CEO Dr. David Torchiana said the job cuts were a financial necessity, adding that most sectors outsource call centers and back-office functions. During the SARS-CoV-2 pandemic, Partners HealthCare, who reported operating income of $484 million (3.5% operating margin) in fiscal year 2019, refused hazard pay to its healthcare workers despite lack of proper PPE. However, they did not layoff or furlough any employees during the pandemic, while cutting executive salaries. The system explained it does not calibrate pay and benefits based upon patients' conditions, because a core part of its mission is delivering the same high-quality care to all patients regardless of the severity of their condition. Partners also provided employees with pay and benefits for those unable to work due to COVID-related illness, eight weeks of pay for those temporarily without work, and hotel rooms for employees. Mass General Brigham reported a loss of operations of $432 million (−2.6% operating margin) in fiscal year 2022 due to historic cost inflation, significant workforce shortages, and a worsening capacity crisis. Many health care systems and hospitals nationwide are experiencing the worst year financially since the start of the COVID-19 pandemic. In response, the system announced its plan for a long-term sustainable future, which includes the following initiatives: Advancing integration to improve patient care and identify efficiencies, addressing the labor shortage by building workforce pipelines, and reducing expenses.


See also

* Partners Harvard Medical International * Steward Health Care System


References


External links

*
Partners International Medical Services

Spaudling Rehabilitation Network

Partners Healthcare At Home
{{authority control 1994 establishments in Massachusetts Healthcare in Boston Hospital networks in the United States Life sciences industry Massachusetts General Hospital Non-profit organizations based in Boston Medical and health organizations based in Massachusetts