David Prangishvili (born 1948) is a virologist, Professor at the

Pasteur Institute The Pasteur Institute (, ) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. Th ...

of Paris, and foremost authority on viruses infecting

Archaea Archaea ( ) is a Domain (biology), domain of organisms. Traditionally, Archaea only included its Prokaryote, prokaryotic members, but this has since been found to be paraphyletic, as eukaryotes are known to have evolved from archaea. Even thou ...

Biography

David Prangishvili gained a Master of Science degree in 1971 at Tbilisi State University,

Georgia Georgia most commonly refers to: * Georgia (country), a country in the South Caucasus * Georgia (U.S. state), a state in the southeastern United States Georgia may also refer to: People and fictional characters * Georgia (name), a list of pe ...

, and a PhD (1977) and Habilitation (1989) from Institute of Molecular Biology of the USSR Academy of Sciences,

Moscow Moscow is the Capital city, capital and List of cities and towns in Russia by population, largest city of Russia, standing on the Moskva (river), Moskva River in Central Russia. It has a population estimated at over 13 million residents with ...

. He pioneered research on

, the third domain of life, in the USSR and in 1986-1991 was a head of the department of Molecular Biology of Archaea at the Georgian Academy of Sciences, Tbilisi. In 1991-2004 he has worked in

Germany Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total popu ...

, at Max-Planck Institute for Biochemistry and at Regensburg University. Since 2004 he is working at the

of Paris. David Prangishvili received a prize of Council of Ministers of the USSR for Excellence in Science and Technology in 1979. David Prangishvili has been elected Member of the

Academia Europaea The Academia Europaea is a pan-European Academy of humanities, letters, law, and sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europe ...

(2018), Member of th
European Academy of Microbiology
(2015), Foreign Member of th

(2011), visiting professor of Chinese Academy of Sciences (2015).

Works

David Prangishvili has affected the field of prokaryotic virology by the discovery and description of many new species and families of DNA viruses which infect Archaea, encompassing families '' Ampullaviridae'' (1), '' Bicaudaviridae'' (2), '' Clavaviridae'' (3), '' Globuloviridae'' (4), '' Guttaviridae'' (5), '' Spiraviridae'' (6) ''Tristromaviridae'' (7), and ''Portogloboviridae'' (8), and the order '' Ligamenvirales'' (9) (families '' Rudiviridae'' (10) and '' Lipothrixviridae'' (11) ). He is an author of more than 170 publications in scientific journals and books. Prangishvili’s studies have helped to reveal that DNA viruses of Archaea constitute a distinctive part of the viral world and that Archaea can be infected by viruses with a variety of unusual morphologies which have not been observed among viruses from the other two domains of life, Bacteria and Eukarya. The results of his research provide new perspectives concerning the diversity and evolution of viruses and virus-host interactions. (12-14)

Publications

1. Häring M., Rachel R, Peng X, Garrett RA, and Prangishvili D (2005) “Diverse viruses in hot springs of Pozzuoli, Italy, including a unique bottle-shaped archaeal virus ABV from a new family, the Ampullaviridae”. J Virol 147: 2419-2429. 2. Häring M, Vestergaard G, Rachel R, Chen L, Garrett RA and Prangishvili D (2005) “Independent virus development outside a host”. Nature 436: 1101-1102. 3. Mochizuki T, Yoshida T, Tanaka R, Forterre P, Sakob Y, and Prangishvili D (2010) “Diversity of viruses of the hyperthermophilic archaeal genus Aeropyrum, and isolation of the Aeropyrum pernix bacilliform virus 1, APBV1, the first representative of the family Clavaviridae”. Virology 402: 347-354. 4. Häring M, Peng X, Brügger K, Rachel R, Stetter KO, Garrett RA, and Prangishvili D (2004) “Morphology and genome organization of the virus PSV of the hyperthermophilic archaeal genera Pyrobaculum and Thermoproteus: a novel virus family, the Globuloviridae”. Virology 323: 233–242. 5. Mochizuki T, Sako Y, and Prangishvili D (2011) "Provirus induction in hyperthermophilic Archaea: Characterization of Aeropyrum pernix spindle-shaped virus 1 and Aeropyrum pernix ovoid virus 1". J Bacteriol 193:5412-5419. 6. Mochizuki T, Krupovic M, Pehau-Arnaudet G, Sako Y, Forterre P, and Prangishvili D (2012). "Archaeal virus with exceptional virion architecture and the largest single-stranded DNA genome". Proc Natl Acad Sci USA 109: 13386–13391. 7. Rensen E, Mochizuki T, Quemin E, Schouten S, Krupovic M, and Prangishvili D (2016) “Novel virus of hyperthermophilic archaea with a unique architecture among DNA viruses”. Proc Nat. Acad Sci USA 113: 2478-2483. 8. Liu Y, Ishino S, Ishino Y, Pehau-Arnaudet G, Krupovic M, and Prangishvili D (2017) “A novel type of polyhedral viruses infecting hyperthermophilic archaea”. J Virol. 91: e00589-17. 9. Prangishvili D, and Krupovic M (2012). “A new proposed taxon for double-stranded DNA viruses, the order Ligamenvirales”. Arch Virol 157: 791–795. 10. Prangishvili D, Arnold HP, Götz D, Ziese U, Holz I, Kristjansson JK and Zillig W (1999) “A novel virus family, the Rudiviridae: Structure, virus-host interactions and genome variability of the Sulfolobus viruses SIRV1 and SIRV2”. Genetics 152:1387–1396. 11. Bettstetter M, Peng, X, Garrett RA, and Prangishvili D (2003) “AFV1, a novel virus infecting hyperthermophilic archaea of the genus Acidianus”. Virology 315: 68-79. 12. Prangishvili D. (2013) “The wonderful world of archaeal viruses”. Annu Rev Microbiol 67: 565-585. 13 Prangishvili D (2015) “Archaeal viruses: living fossils of the ancient virosphere?” Ann NY Acad Sci 1341: 35-40. 14. Prangishvili D, Bamford DH, Forterre P, Iranzo J., Koonon EV, and Krupovic M (2017) “The enigmatic archaeal virosphere”. Nature Rev Microbiol 15: 724–739.

References

{{DEFAULTSORT:Prangishvili, David 1948 births Virologists from Georgia (country) Living people Soviet virologists Members of Academia Europaea