Daniel K. Nomura is an American chemical biologist and Professor of Chemical Biology and Molecular Therapeutics at the University of California, Berkeley, in the Departments of Chemistry and Molecular & Cell Biology. His work employs chemoproteomic approaches to develop small molecule therapeutics and therapeutic modalities against traditionally "undruggable" proteins.
He is a member of the scientific advisory committee of the Mark Foundation for Cancer Research, a foundation set up by billionaire
Alexander Knaster
Alexander Knaster (born 19 February 1959) is a British businessman. A billionaire, he is founder of Pamplona Capital Management.
Biography
Knaster was born in Moscow in 1959 to a Jewish family of academics.UC Berkeley, studying under the mentorship of John Casida. He went on to perform his postdoctoral research with Ben Cravatt at Scripps Research in La Jolla, California. There he discovered a role for monoacylglycerol lipase in generating oncogenic signaling lipids that promote cancer and in proinflammatory cascades that impact neurodegenerative disorders. In 2011, Nomura started his independent research group at UC Berkeley. His work focuses on implementing chemoproteomic platforms to develop small molecule therapeutics against traditionally "undruggable" proteins. These approaches have led to the discovery of novel inhibitors and new ligands that expand the scope of proteolysis targeting chimeras (
PROTACS
A proteolysis targeting chimera (PROTAC) is a heterobifunctional small molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. Rather than acting as a conventional enzyme inhibitor, a PROTAC works by ...
), which are bifunctional molecules that harness the cells ubiquitin-proteasome system to degrade targets of interest. Notable recent discoveries include an inhibitor of mTORC1, a molecular glue between UBR7 and p53 that activates p53 tumor suppressor activity, a covalent inhibitor against MYC, novel covalent recruiters against E3 ubiquitin ligases such as RNF114, RNF4, and FEM1B for targeted protein degradation applications, the Deubiquitinase Targeting Chimera (DUBTAC) platform for targeted protein stabilization, and a chemical rational design strategy for developing molecular glue degraders. In 2017, Nomura became the Director of the Novartis-Berkeley Translational Chemical Biology Institute, which aims to develop chemical technologies and therapeutics against undruggable targets. Nomura is also co-founder o Frontier Medicines an Vicinitas Therapeutics
Awards
* 2019 Mark Foundation for Cancer Research ASPIRE award
* 2022 National Cancer Institute Outstanding Investigator Award