Dipeptidyl peptidase 8 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''DPP8''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
This gene encodes a member of the
peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a
prolyl bond. The encoded protein shares similarity with
dipeptidyl peptidase-4 in that it is ubiquitously expressed, and
hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in
T-cell activation and immune function. Alternatively spliced transcript variants encoding different
isoforms have been described.
A relatively specific inhibitor of DPP8 and
DPP9, Val-boroPro
-,
leads to increased activation of the
inflammasome though both NLRBP1 and
CARD8 and can trigger
pyroptosis.
References
;Notes
;Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
{{gene-15-stub