The τ and γ subunits are part of the

DNA polymerase III holoenzyme DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg (son of Arthur Kornberg) and Malcolm Gefter in 1970. The complex has high processivity (i.e. the number ...

of prokaryotes. The protein family is characterized by the well-conserved first N-terminal domain, approx. 365 amino acids. The eukaryotic equivalent to the DNA clamp loader is

replication factor C The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication. The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 in ''Saccharomyces cerevisiae''. RFC is used in eukaryo ...

, with the subunits RFC1, RFC2,

RFC3 Replication factor C subunit 3 is a protein that in humans is encoded by the ''RFC3'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA t ...

, RFC4, and RFC5. The domain is also found in plants as gene STICHEL (STI), with similarity to cyanobacterial sequences. However, STI in plants is nuclear-localized and does not participate in genome duplication. It seems to instead regulate branching.

References

Bacterial proteins Protein families DNA replication {{molecular-biology-stub