Dynein axonemal intermediate chain 2 also known as axonemal dynein intermediate chain 2, is a
protein that in humans is encoded by the ''DNAI2''
gene.
Function
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the
dynein
Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells. They convert the chemical energy stored in ATP to mechanical work. Dynein transports various cellular cargos, provides forces and displacements importa ...
complex of respiratory cilia and sperm flagella.
Clinical significance
Mutations in the ''DNAI2'' gene are associated with
primary ciliary dyskinesia.
References
External links
GeneReviews/NCBI/NIH/UW entry on Primary Ciliary Dyskinesia
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