DMPX (3,7-dimethyl-1-propargylxanthine) is a
caffeine
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class and is the most commonly consumed Psychoactive drug, psychoactive substance globally. It is mainly used for its eugeroic (wakefulness pr ...
analog which displays affinity for A
2 adenosine receptor
The adenosine receptors (or P1 receptors) are a class of Purinergic receptor, purinergic G protein-coupled receptors with adenosine as the endogenous ligand (biochemistry), ligand. There are four known types of adenosine receptors in humans: Aden ...
s, in contrast to the A
1 subtype receptors.
DMPX had 28 times and 15 times higher potency than caffeine in blocking, respectively, the peripheral and central effects of the adenosine agonist
NECA. The locomotor stimulation caused by DMPX (ED
50 10 ''μ''mol/kg) was similarly higher than caffeine.
See also
*
DPCPX
*
8-PT
*
CPX (8-CPT)
*
8-Chlorotheophylline
*
Theophylline
Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. It is used to treat chronic obstructive pulmonary disease (COPD) and asthma. Its pharmacology is similar to other met ...
References
{{Adenosinergics
Adenosine receptor antagonists
Anxiogenics
Caffeine
Designer drugs
Vasoconstrictors
Propargyl compounds