Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a
protein that in humans is encoded by the ''DLGAP5''
gene.
DLG7 is a
kinetochore protein that stabilizes
microtubule
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 an ...
s in vicinity of
chromosomes. DLG7 controls
spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.
DGL7 is a part of
Ran-dependent complex.
Stabilization of DGL7 in cell occurs due to phosphorylation by
Aurora A kinase.
Expression of DGL7 is found in cancer
and
stem cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...
s.
References
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External links
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