Death effector domain containing protein is a
protein that in humans is encoded by the ''DEDD''
gene.
Function
This gene encodes a protein that contains a death effector
domain (DED). DED is a
protein–protein interaction domain shared by adaptors, regulators and executors of the
programmed cell death pathway.
Overexpression of this gene was shown to induce weak
apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...
. Upon stimulation, this protein was found to
translocate from cytoplasm to nucleus and colocalize with
UBTF, a basal factor required for
RNA polymerase I transcription, in the
nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
Interactions
DEDD has been shown to
interact with:
*
CFLAR
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the ''CFLAR'' gene. Also called c-FLIP (FLICE
Caspase-8 is a caspase protein, encoded by the ''CASP8'' gene. It most likely acts upon caspase-3.
''CASP8'' ortholo ...
,
[
* Caspase 8,]
References
Further reading
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