D-aspartate oxidase In enzymology, a D-aspartate oxidase () is an enzyme that catalyzes the chemical reaction :D-aspartate + H2O + O2 \rightleftharpoons oxaloacetate + NH3 + H2O2 The 3 substrates of this enzyme are D-aspartate, H2O, and O2, whereas its 3 prod ...

is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

that is encoded by the ''DDO''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and ''N''-methyl D-aspartate.

Flavin adenine dinucleotide In biochemistry, flavin adenine dinucleotide (FAD) is a redox-active coenzyme associated with various proteins, which is involved with several enzymatic reactions in metabolism. A flavoprotein is a protein that contains a flavin group, which ma ...

or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to ) transcript variants encoding different isoforms have been found for this gene.

References

Further reading