Doublecortin domain-containing protein 2 (DCDC2) is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''DCDC2''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind

tubulin Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cytosk ...

and enhance microtubule polymerization.

Clinical significance

Mutations in this gene have been associated with reading disability (RD), also referred to as developmental dyslexia. But this is controverse since a recent study proposed that there is a "low likelihood of a direct deletion effect on reading skills." Changes in the DCDC2 gene are frequently found among dyslexics. Altered

allele An allele is a variant of the sequence of nucleotides at a particular location, or Locus (genetics), locus, on a DNA molecule. Alleles can differ at a single position through Single-nucleotide polymorphism, single nucleotide polymorphisms (SNP), ...

s often occur among children with

reading Reading is the process of taking in the sense or meaning of symbols, often specifically those of a written language, by means of Visual perception, sight or Somatosensory system, touch. For educators and researchers, reading is a multifacete ...

and

writing Writing is the act of creating a persistent representation of language. A writing system includes a particular set of symbols called a ''script'', as well as the rules by which they encode a particular spoken language. Every written language ...

difficulties. The gene appears to have a strong linkage with the processing of speech information when writing. *

Function

Clinical significance

References

Further reading