Death-associated protein kinase 3 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''DAPK3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Death-associated protein kinase 3 (DAPK3) induces
morphological changes in
apoptosis
Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...
when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.
Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.
Interactions
DAPK3 has been shown to
interact with
PAWR
PRKC apoptosis WT1 regulator protein, or Prostate apoptosis response-4, is a tumor-suppressor protein coded for in the human by the ''PAWR'' gene, that induces apoptosis in cancer cells, but not in normal cells.
Function
The tumor suppressor ...
and
Death associated protein 6.
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References
Further reading
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EC 2.7.11
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