DADLE ( small>D-Ala², D-Leu⁵Enkephalin) is a synthetic opioid peptide with

analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...

properties. Although it is often considered a selective

delta opioid receptor Delta commonly refers to: * Delta (letter) (Δ or δ), a letter of the Greek alphabet * River delta, at a river mouth * D ( NATO phonetic alphabet: "Delta") * Delta Air Lines, US * Delta variant of SARS-CoV-2 that causes COVID-19 Delta may als ...

agonist, it also binds to the μ₁ subtype of mu opioid receptors. Treatment with DADLE results in transient depression of mean

arterial An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pul ...

blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressur ...

and

heart rate Heart rate (or pulse rate) is the frequency of the heartbeat measured by the number of contractions (beats) of the heart per minute (bpm). The heart rate can vary according to the body's physical needs, including the need to absorb oxygen and e ...

.Online Medical Dictionary, enkephalin, leucine-2-alanine
/ref> Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.

References

Synthetic opioids Opioid peptides Mu-opioid receptor agonists Delta-opioid receptor agonists {{analgesic-stub

See also

References