The enzyme cysteine-''S''-conjugate β-lyase (EC 4.4.1.13)

catalyzes Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycl ...

the

chemical reaction A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ...

:an L-cysteine-''S''-conjugate + H₂O = a thiol + NH₃ + pyruvate (overall reaction) ::(1a) an L-cysteine-''S''-conjugate = a thiol + 2-aminoprop-2-enoate ::(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous) ::(1c) 2-iminopropanoate + H₂O = pyruvate + NH₃ (spontaneous) This enzyme belongs to the family of

lyase In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bond A chemical bond is a lasting attraction between atoms or ions that enables the formation of molecules and crystals. The bon ...

s, specifically the class of carbon-sulfur lyases. The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...

of this enzyme class is L-cysteine-''S''-conjugate thiol-lyase (deaminating; pyruvate-forming). Other names in common use include cysteine conjugate β-lyase, glutamine transaminase K/cysteine conjugate β-lyase, and L-cysteine-''S''-conjugate thiol-lyase (deaminating). It employs one cofactor,

pyridoxal phosphate Pyridoxal phosphate (PLP, pyridoxal 5'- phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-depende ...

Structural studies

As of late 2007, 3

structures A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such a ...

have been solved for this class of enzymes, with

PDB PDB may refer to: * Chess Problem Database Server (PDB Server) * 1,4-Dichlorobenzene (paradichlorobenzene) * Party of German-speaking Belgians, (German: '), a political party and predecessor of the ProDG * PDB (Palm OS), a container format for reco ...

accession codes , , and .

References

* EC 4.4.1 Pyridoxal phosphate enzymes Enzymes of known structure {{lyase-stub