Cyclazocine is a mixed

opioid Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioi ...

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

/ antagonist related to

dezocine Dezocine, sold under the brand name Dalgan, is an atypical opioid analgesia, analgesic which is used in the treatment of pain. It is used by intravenous infusion and intramuscular injection. Dezocine is an opioid receptor receptor modulator, mod ...

, pentazocine and

phenazocine Phenazocine (brand names Prinadol, Narphen) is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects. Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at ...

. This family of opioid drugs is called the

benzomorphan Benzomorphan is a chemical compound that is the base for a series of drugs which variably act on the opioid kappa and sigma receptors, including the following compounds: * 5,9-DEHB * 8-CAC * Alazocine * Anazocine * Bremazocine * Butinazocine ...

s or benzazocines. It is a KOR agonist and

MOR Mor or MOR may refer to: Names and titles * Mór (given name), a list of people named Mór or Mor * Mor (surname), a list of people named Mor or Mór * Mor (honorific), or Mar, in Syriac Radio and television * Middle of the road (music) genre * ...

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonist ...

, and also has high affinity for the

DOR DOR, Dor, or DoR may refer to: Computer games and characters * '' Advance Wars: Days of Ruin'', a turn-based tactics video game for the Nintendo DS * Dor, a magician in the fictional Xanth universe; see Magicians of Xanth * ''WWE Day of Reckoning ...

Use

Research into the use of cyclazocine for the treatment of

bipolar Bipolar may refer to: Astronomy * Bipolar nebula, a distinctive nebular formation * Bipolar outflow, two continuous flows of gas from the poles of a star Mathematics * Bipolar coordinates, a two-dimensional orthogonal coordinate system * Bipolar ...

patients with depression was undertaken by Fink and colleagues (1970). It showed that 8 out of 10 patients experienced moderate improvement. Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting treatment of narcotic addiction was severely hampered by the drug's psychotomimetic, dysphoric, and hallucinatory effects. The dysphoric/ anxiety inducing effects of the drug correlate with increasing dosage and would likely reduce the risk of abuse in the same manner as other opioids which preferentially act on the KOR versus the

and

, although the side-effect threshold is often lower than the lowest effective dose.

References

{{Sigma receptor modulators Synthetic opioids Phenols Benzomorphans Kappa-opioid receptor agonists

Use

See also

References