Crodowaldo Pavan
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Crodowaldo Pavan (; 1 December 1919 – 3 April 2009) was a Brazilian
biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological inter ...
and
geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic process ...
, and a scientific leader in
Brazil Brazil, officially the Federative Republic of Brazil, is the largest country in South America. It is the world's List of countries and dependencies by area, fifth-largest country by area and the List of countries and dependencies by population ...
.


Early life

Pavan was born to a family of second-generation
immigrant Immigration is the international movement of people to a destination country of which they are not usual residents or where they do not possess nationality in order to settle as permanent residents. Commuters, tourists, and other short- ...
s from
Italy Italy, officially the Italian Republic, is a country in Southern Europe, Southern and Western Europe, Western Europe. It consists of Italian Peninsula, a peninsula that extends into the Mediterranean Sea, with the Alps on its northern land b ...
in 1919, in the city of
Campinas Campinas (, ''Plains'' or ''Meadows'') is a Brazilian Municipalities of Brazil, municipality in São Paulo (state), São Paulo State, part of the country's Southeast Region, Brazil, Southeast Region. According to the 2020 estimate, the city's popul ...
,
São Paulo state SAO or Sao may refer to: Places * Sao civilisation, in Middle Africa from 6th century BC to 16th century AD * Sao, a town in Boussé Department, Burkina Faso * Serb Autonomous Regions (''Srpska autonomna oblast'', SAO), during the breakup of ...
, Brazil. His great-grandfather was an expert in textile paints and a militant
anarchist Anarchism is a political philosophy and Political movement, movement that seeks to abolish all institutions that perpetuate authority, coercion, or Social hierarchy, hierarchy, primarily targeting the state (polity), state and capitalism. A ...
, who was frequently persecuted and imprisoned in Italy as well as in Brazil for his political activism. As a boy, influenced by his father's
porcelain Porcelain (), also called china, is a ceramic material made by heating Industrial mineral, raw materials, generally including kaolinite, in a kiln to temperatures between . The greater strength and translucence of porcelain, relative to oth ...
manufacturing plant at
Mogi das Cruzes Mogi das Cruzes ( or ) is a municipality in the state of São Paulo, Brazil, located within the metropolitan region of the state capital of the city of São Paulo. The population is 451,505 (2022 census) in an area of 713 km2. It is located 4 ...
, he wished to follow a career in
engineering Engineering is the practice of using natural science, mathematics, and the engineering design process to Problem solving#Engineering, solve problems within technology, increase efficiency and productivity, and improve Systems engineering, s ...
, but changed radically when he had the opportunity in
high school A secondary school, high school, or senior school, is an institution that provides secondary education. Some secondary schools provide both ''lower secondary education'' (ages 11 to 14) and ''upper secondary education'' (ages 14 to 18), i.e., ...
to attend a lecture by noted
French French may refer to: * Something of, from, or related to France ** French language, which originated in France ** French people, a nation and ethnic group ** French cuisine, cooking traditions and practices Arts and media * The French (band), ...
physician and professor André Dreyfus and a screening of the film " The Story of Louis Pasteur", starring Oscar-winning actor
Paul Muni Paul Muni (born Frederich Meshilem Meier Weisenfreund; September 22, 1895 – August 25, 1967) was an American stage and film actor from Chicago. He started his acting career in the Yiddish theater and during the 1930s, he was considered one of ...
in the title role.


Studies

Following Dreyfus' advice, in 1938 he enrolled in a course of
natural history Natural history is a domain of inquiry involving organisms, including animals, fungi, and plants, in their natural environment, leaning more towards observational than experimental methods of study. A person who studies natural history is cal ...
at the
University of São Paulo The Universidade de São Paulo (, USP) is a public research university in the Brazilian state of São Paulo, and the largest public university in Brazil. The university was founded on 25 January 1934, regrouping already existing schools in ...
, continuing to work in biological research under his mentor. His doctoral thesis on the subject of the blind
cave fish Cavefish or cave fish is a generic term for fresh and brackish water fish adapted to life in caves and other underground habitats. Related terms are subterranean fish, troglomorphic fish, troglobitic fish, stygobitic fish, phreatic fish, and ...
'' Pimelodella kronei'' ( syn. ''Typhlobagrus kronci'') was completed in the same institution. In 1942, he accepted a position as assistant professor at the University of São Paulo, and quickly became a full professor, a position he held until his retirement in 1978. In 1942, Pavan became involved in a pioneering research project on the
genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...
,
taxonomy image:Hierarchical clustering diagram.png, 280px, Generalized scheme of taxonomy Taxonomy is a practice and science concerned with classification or categorization. Typically, there are two parts to it: the development of an underlying scheme o ...
and
ecology Ecology () is the natural science of the relationships among living organisms and their Natural environment, environment. Ecology considers organisms at the individual, population, community (ecology), community, ecosystem, and biosphere lev ...
of ''
Drosophila ''Drosophila'' (), from Ancient Greek δρόσος (''drósos''), meaning "dew", and φίλος (''phílos''), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or p ...
'' fruit flies, financed by the
Rockefeller Foundation The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The foundation was created by Standard Oil magnate John D. Rockefeller (" ...
under the direction of the noted Russian-American biologist
Theodosius Dobzhansky Theodosius Grigorievich Dobzhansky (; ; January 25, 1900 – December 18, 1975) was a Russian-born American geneticist and evolutionary biologist. He was a central figure in the field of evolutionary biology for his work in shaping the modern ...
. This subject became Pavan's lifelong research interest and the source of his international recognition. In particular, Dr. Pavan introduced into biology the cytogenetical study of '' Rhynchosciara angelae'', a fly which is noted for its giant
chromosome A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most import ...
s, thus facilitating the determination of the loci of
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
s. He and his collaborators were among the first to prove that the structure of genes and chromosomes was not fixed and could be changed by
infection An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...
s. In 1966, Pavan accepted an invitation from the
Oak Ridge National Laboratory Oak Ridge National Laboratory (ORNL) is a federally funded research and development centers, federally funded research and development center in Oak Ridge, Tennessee, United States. Founded in 1943, the laboratory is sponsored by the United Sta ...
in
Tennessee Tennessee (, ), officially the State of Tennessee, is a landlocked U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders Kentucky to the north, Virginia to the northeast, North Carolina t ...
to establish a laboratory for further investigation on cellular genetics. In 1968, he accepted an invitation to become a
tenure Tenure is a type of academic appointment that protects its holder from being fired or laid off except for cause, or under extraordinary circumstances such as financial exigency or program discontinuation. Academic tenure originated in the United ...
d
full professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a 'person who professes'. Professors ...
at the
University of Texas at Austin The University of Texas at Austin (UT Austin, UT, or Texas) is a public university, public research university in Austin, Texas, United States. Founded in 1883, it is the flagship institution of the University of Texas System. With 53,082 stud ...
, in
Austin, Texas Austin ( ) is the List of capitals in the United States, capital city of the U.S. state of Texas. It is the county seat and most populous city of Travis County, Texas, Travis County, with portions extending into Hays County, Texas, Hays and W ...
. He returned to Brazil in 1975, and, after officially retiring from his post at the University of São Paulo, he accepted the position of full professor at the recently founded
State University of Campinas The University of Campinas (), commonly called Unicamp, is a public research university in the state of São Paulo (state), São Paulo, Brazil. Established in 1962, Unicamp was designed from scratch as an integrated Research institute, researc ...
, working as departmental chairman and dean of the Instituto de Biologia da Universidade Estadual de Campinas (Institute of Biology) until a second retirement. He was an
emeritus professor ''Emeritus/Emerita'' () is an honorary title granted to someone who retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". In some c ...
at both universities.


Influence

As a scientific leader, Pavan was very influential and became involved in the main development of
science and technology in Brazil Science and technology in Brazil has entered the international arena in recent decades. The central agency for science and technology in Brazil is the Ministry of Science and Technology, which includes the CNPq and Finep. This ministry also ...
in the second half of the 20th century. He was president of the National Research Council (
CNPq The National Council for Scientific and Technological Development (CNPq, , earlier ) is a government agency under the Ministry of Science and Technology of the Brazilian federal government. The council is dedicated to the promotion of scientific ...
) from 1986 to 1990, and president of the Brazilian Society for the Advancement of Science from 1980 to 1986, a critical period for the redemocratization of the country, when the Society played a leading role in civil resistance to the military government. Pavan was a member of several international scientific societies, such as the
Third World Academy of Sciences The World Academy of Sciences for the advancement of science in developing countries (TWAS) is a merit-based science academy established for developing countries, uniting more than 1,400 scientists in some 100 countries. Its principal aim is t ...
, the
Academy of Sciences of Lisbon The Academy of Sciences of Lisbon () is Portugal's national academy dedicated to the advancement of sciences and learning, with the goal of promoting academic progress and prosperity in Portugal. It is one of Portugal's most prestigious scientif ...
, the
Royal Physiographic Society in Lund The Royal Physiographic Society in Lund (), is one of the Royal Academies in Sweden. It was founded in Lund, on December 2, 1772, and received a Royal Charter by Gustav III, on March 6, 1778.Academy of Sciences of Chile, and received decorations, medals, and awards from several countries. He was one of the few Brazilians who was a member of the
Pontifical Academy of Sciences The Pontifical Academy of Sciences (, ) is a Academy of sciences, scientific academy of the Vatican City, established in 1936 by Pope Pius XI. Its aim is to promote the progress of the mathematical, physical, and natural sciences and the study ...
. He was also a member of the
Brazilian Academy of Sciences Brazilian commonly refers to: * Brazil, a country * Brazilians, its people * Brazilian Portuguese, its dialect Brazilian may also refer to: * "The Brazilian", a 1986 instrumental music piece by Genesis * Brazilian Café, Baghdad, Iraq (1937) * Bra ...
, and one of the founders of the Academy of Sciences of São Paulo, the Academy of Medicine of São Paulo, the Academy of Letters of São Paulo, the Academy of Education of São Paulo, and the Brazilian Society of Genetics as well as one of its presidents. During the final part of his life Pavan lived in
São Paulo São Paulo (; ; Portuguese for 'Paul the Apostle, Saint Paul') is the capital of the São Paulo (state), state of São Paulo, as well as the List of cities in Brazil by population, most populous city in Brazil, the List of largest cities in the ...
and was involved in several activities related to the
public understanding of science ''Public Understanding of Science'' is a bimonthly peer-reviewed academic journal established in 1992 and published by SAGE Publications. It covers topics in the popular perception of science, the role of science in society, philosophy of scienc ...
. He was one of the founders and directors of the Brazilian Association for Scientific Dissemination, and was still active in research on the
biological control Biological control or biocontrol is a method of controlling pests, whether pest animals such as insects and mites, weeds, or pathogens affecting animals or plants by using other organisms. It relies on predation, parasitism, herbivory, or o ...
of agricultural plagues.


Death

Pavan died on April 3, 2009, at the University Hospital of the
University of São Paulo The Universidade de São Paulo (, USP) is a public research university in the Brazilian state of São Paulo, and the largest public university in Brazil. The university was founded on 25 January 1934, regrouping already existing schools in ...
, of
multiple organ failure Multiple organ dysfunction syndrome (MODS) is altered organ function in an acutely ill patient requiring immediate medical intervention. There are different stages of organ dysfunction for certain different organs, both in acute and in chronic ...
resultant of complications after a
cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...
surgery.


Decorations

*Comendador da Ordem do Rio Branco - Ministério das Relações Exteriores - 1986 *Oficial da Ordem do Mérito - Forças Armadas do Brasil - 1986 *Ordem da Inconfidência - Governo do Estado de Minas Gerais - 1987 *Grande Oficial da Ordem do Mérito - Governo da Republica Portuguesa - 1987 *Grã-Cruz da Ordem Nacional do Mérito Científico - Presidency of the Republic of Brazil - 1994


Medals

*Medalha "Anchieta" - Câmara de Vereadores da cidade de São Paulo - 1988 *Medalha CAPES 50 Anos - CAPES/MEC - Jul/2001


Awards

*Prêmio Nacional de Genética - 1963 *Prêmio Moinho Santista (Biologia) - Fundação Moinho Santista - 1980 *Prêmio "Alfred Jurzykowski" -
Academia Nacional de Medicina The Academia Nacional de Medicina (ANM) is the Brazilian national academy of medicine. The academy was founded during the Brazilian imperial period on 30 June 1829, under the name of ''Sociedade de Medicina do Rio de Janeiro''. On 8 Ma ...
- 1986


Selected publications

* PAVAN, C. and BREUER, M. E. 1952. Polytene chromosomes in different tissues of ''Rhynchosciara''. ''Journal of Heredity''. vol. 63, p. 151-157. * PAVAN, C. 1967. Chromosomal changes induced by infective agents Triangle. ''Sandoz J. Med. Sci.'' vol. 8, p. 42-48. * PAVAN, C., BIESELE, J., RIESS, R. W. and WERTZ, A. V. 1971. XIII. Changes in the ultrastructure of ''Rhynchosciara'' cells infected by ''Microsporidia''. ''Studies in Genetics''. vol. VI, p. 7103. * PAVAN, C., DA CUNHA, A. B. and MORSOLETTO, C. 1971. Virus-chromosome relationships in cells of ''Rhynchosciara'' (''Diptera'', ''Sciaridae''). ''Caryologia''. vol. 24, p. 371-389. * PAVAN, C. and SANDERS, P. F. 1972. Heterochromatin in development of normal and infected cells. ''In Cell Differentiation''. Munrsgaard- Copenhagen:. * PAVAN, C. 1983. Karyotypes and possible regions of origin of three species of ''Calliphoridae'' (''Diptera'') recently introduced in Brazil. ''Revista Brasileira de Genética''. vol. 6, p. 619-638.


External links


Biography
Brazilian Academy of Sciences.

{{DEFAULTSORT:Pavan, Crodowaldo 1919 births 2009 deaths Members of the Pontifical Academy of Sciences Brazilian scientists Brazilian geneticists Members of the Brazilian Academy of Sciences Recipients of the National Order of Scientific Merit (Brazil) Brazilian people of Italian descent People from Campinas Brazilian science writers Brazilian educators University of São Paulo alumni Academic staff of the State University of Campinas