Corneliu E. Giurgea (6 January 1923,

Bucharest Bucharest ( , ; ) is the capital and largest city of Romania. The metropolis stands on the River Dâmbovița (river), Dâmbovița in south-eastern Romania. Its population is officially estimated at 1.76 million residents within a greater Buc ...

– 30 December 1995,

Brussels Brussels, officially the Brussels-Capital Region, (All text and all but one graphic show the English name as Brussels-Capital Region.) is a Communities, regions and language areas of Belgium#Regions, region of Belgium comprising #Municipalit ...

) was a Romanian

psychologist A psychologist is a professional who practices psychology and studies mental states, perceptual, cognitive, emotional, and social processes and behavior. Their work often involves the experimentation, observation, and explanation, interpretatio ...

and

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...

. In 1964 he synthesised

Piracetam Piracetam is a drug that has efficacy in cognitive disorders, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia; sources differ on its usefulness for dementia. Piracetam is sold as a medication in many European countries. Piracetam ...

, which he has described as a

nootropic Nootropics ( or ) (colloquially brain supplements, smart drugs, cognitive enhancers, memory enhancers, or brain boosters) are chemical substances which purportedly improve cognitive functions, such as attention, memory, wakefulness, and self ...

. Giurgea coined the term ''nootropic'' in 1972.

Nootropic characteristics

He stated that nootropic drugs should have the following characteristics: # They should enhance

learning Learning is the process of acquiring new understanding, knowledge, behaviors, skills, value (personal and cultural), values, Attitude (psychology), attitudes, and preferences. The ability to learn is possessed by humans, non-human animals, and ...

and

memory Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembe ...

. # They should enhance the resistance of learned behaviors/memories to conditions which tend to disrupt them (e.g. electroconvulsive shock, hypoxia). # They should protect the brain against various physical or chemical injuries (e.g.

barbiturate Barbiturates are a class of depressant, depressant drugs that are chemically derived from barbituric acid. They are effective when used medication, medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological a ...

s, scopalamine). # They should increase the efficacy of the tonic cortical/subcortical control mechanisms. # They should lack the usual pharmacology of other

psychotropic A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, psychoactive substance, or psychotropic substance is a chemical substance that alters psychological functioning by modulating central nervous system acti ...

drugs (e.g.

sedation Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, ...

, motor stimulation) and possess very few

side effect In medicine, a side effect is an effect of the use of a medicinal drug or other treatment, usually adverse but sometimes beneficial, that is unintended. Herbal and traditional medicines also have side effects. A drug or procedure usually use ...

s and extremely low

toxicity Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacteria, bacterium, or plant, as well as the effect o ...

Biography

He received a Ph.D. in

medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...

from the

University of Bucharest The University of Bucharest (UB) () is a public university, public research university in Bucharest, Romania. It was founded in its current form on by a decree of Prince Alexandru Ioan Cuza to convert the former Princely Academy of Bucharest, P ...

, where he also taught for several years. He continued his research and specialisation in Psychology (doc) at the First Pavlov State Medical University of St. Peterburg, under some of

Ivan Pavlov Ivan Petrovich Pavlov (, ; 27 February 1936) was a Russian and Soviet experimental neurologist and physiologist known for his discovery of classical conditioning through his experiments with dogs. Pavlov also conducted significant research on ...

's closest collaborators such as Pyotr Kupalov. He was then a

post-doc A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academ ...

at the

University of Rochester The University of Rochester is a private university, private research university in Rochester, New York, United States. It was founded in 1850 and moved into its current campus, next to the Genesee River in 1930. With approximately 30,000 full ...

and subsequently a professor at the

Université catholique de Louvain UCLouvain (or Université catholique de Louvain , French for Catholic University of Louvain, officially in English the University of Louvain) is Belgium's largest French-speaking university and one of the oldest in Europe (originally establishe ...

and scientific counselor and researcher at the Belgian pharmaceutical company UCB.

Books and articles

*''Le Vieillissement Cerebral: Normal Et Reussi, Le Defi Du XXIe Siecle'' 1993 *''L'heritage De Pavlov: Un Demi-Siecle Apres Sa Mort'' 1986 *''Fundamentals to a pharmacology of the mind'' 1981 *Articles
PubMed CentralGoogle Scholar

References

1923 births 1995 deaths Romanian psychologists Romanian chemists Jewish chemists Romanian pharmacologists University of Bucharest alumni Academic staff of the University of Bucharest Academic staff of the Université catholique de Louvain 20th-century psychologists Romanian expatriates in the Soviet Union Romanian expatriates in the United States Romanian expatriates in Belgium {{Psychologist-stub