The Core binding factor (CBF) is a group of
heterodimeric transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s.
Core binding factors are composed of:
* a non-
DNA-binding CBFβ chain (
CBFB)
* a DNA-binding CBFα chain (
RUNX1,
RUNX2,
RUNX3)
References
*
See also
*
AI-10-49, an anti-leukemic drug under development.
External links
*
Transcription factors
{{genetics-stub